{"created":"2023-05-15T09:02:46.253110+00:00","id":3638,"links":{},"metadata":{"_buckets":{"deposit":"3c3461bf-dfea-4c59-8832-99c34142c4a6"},"_deposit":{"created_by":3,"id":"3638","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3638"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003638","sets":["557:561:643"]},"author_link":["11898","11897"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S171","bibliographicPageStart":"S167","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"NF-E2-related factor 2 （Nrf2） regulates the coordinate induction of phase 2 detoxifying and antioxidant\nenzymes in response to xenobiotics and oxidative stress via antioxidant responsive element. Nrf2 knockout mice are\nhighly susceptible to the acute toxicity generated by acetaminophen, butylated hydroxytoluene or hyperoxia and to\ncarcinogenesis induced by benzo[a]pyrene. Recently, it becomes increasingly evident that Nrf2 also plays essential roles\nin the protection against infl ammation. Nrf2 regulates the infl ammation during carrageenin-induced pleurisy and lung\ninfl ammation, wound healing in skin, and dextran sulfate-induced colitis. Nrf2 knockout mice are also susceptible to\nendotoxin-induced septic shock and allergen-induced asthma. Using carrageenin-induced pleurisy and porcine neutrophil\nelastase-induced lung injury models, we proposed that this anti-infl ammatory action of Nrf2 relies on the activities in\nmacrophages. In macrophages, Nrf2 modulates the infl ammatory response by up-regulating a range of anti-oxidative and\nanti-infl ammatory enzymes, such as CD36 and secretory leukoprotease inhibitor（ SLPI）. CD36 is a macrophage class\nB scavenger receptor involved in the uptake of apoptotic neutrophils and microorganisms such as Staphylococcus aureus.\nThus, Nrf2 may play important roles in the protection of infl ammation and innate immune response.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S167-S171","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Center for Advanced Medical Research, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maruyama, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Ken"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S167.pdf","filesize":[{"value":"139.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S167.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3638/files/HirosakiMedJ_59_S167.pdf"},"version_id":"faab8ef1-17e5-48b6-adf8-00ed5302c715"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nrf2","subitem_subject_scheme":"Other"},{"subitem_subject":"antioxidant responsive element(ARE)","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The role of Nrf2 in the protection against infl ammation and innate immunity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The role of Nrf2 in the protection against infl ammation and innate immunity"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3638","relation_version_is_last":true,"title":["The role of Nrf2 in the protection against infl ammation and innate immunity"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:45.090621+00:00"}