{"created":"2023-05-15T09:02:46.468419+00:00","id":3643,"links":{},"metadata":{"_buckets":{"deposit":"11b19aaf-c277-4850-b59c-4b6d4ce85b7d"},"_deposit":{"created_by":3,"id":"3643","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3643"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003643","sets":["557:561:643"]},"author_link":["11919","9445","11920"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S209","bibliographicPageStart":"S202","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"It is well-known that α-melanophore-stimulating hormone （α-MSH） release from the amphibian pars\nintermedia（ PI） depends on the light condition of the animal’s background. In the present study, we present two new\nfunctions of α-MSH in amphibians and mammals. In Xenopus laevis, we show that temperatures below 8 ℃ stimulate\nα-MSH secretion of the PI and skin darkening, with a maximum at 5 ℃, under regulation of the hypothalamus rule,\nindependently from the illumination state of the background. The cold-induced α-MSH release of the PI was inhibited by\nneuropeptide-Y-producing suprachiasmatic-melanotrope-inhibiting neurons in the ventrolateral area of the suprachiasmatic\nnucleus but increasely in thyrotropin-releasing-hormene-containing neurons of the magnocellular nucleus. It is known\nthat intracerebroventricular（ ICV） administration of a low dose of interleukin-1β（ IL-1β） induces hyperalgesia in rat\nand that this eff ect can be inhibited by α-MSH. To identify the part of the brain that is aff ected by hyperalgesiainducing\nIL-1β and the site of α-MSH concerned, we have examined Fos expression in the brain in response to ICV\nmicroinjection of α-MSH and/or IL-1β. Following injection of 10 pg IL-1β, hyperalgesia was induced and Fos became\nexpressed in the paraventricular nucleus（ PVN） of the hypothalamus and in the arcuate nucleus（ ARC）, which contains\nα-MSH-producing neurons. ICV co-injection of IL-1β ・ with 30 ng α-MSH fully inhibited both hyperalgesia and Fos\nexpression in the PVN and the ARC. We conclude that PVN neurons are activated by hyperalgesic IL-1β and propose\nthat this eff ect is abolished by α-MSH released from the ARC but not from the pituitary gland.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S202-S209","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anatomical Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine"},{"subitem_text_value":"Department of Cellular Animal Physiology, Institute for Neuroscience, Radboud University"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tonosaki, Yoshikazu"}],"nameIdentifiers":[{"nameIdentifier":"9445","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugiura, Yasuo"}],"nameIdentifiers":[{"nameIdentifier":"11919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Roubos, Eric W."}],"nameIdentifiers":[{"nameIdentifier":"11920","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S202.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S202.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3643/files/HirosakiMedJ_59_S202.pdf"},"version_id":"c3a4ea93-7f2f-42d2-84e9-156a133666fa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α-melanophore-stimulating hormone (α-MSH)","subitem_subject_scheme":"Other"},{"subitem_subject":"low temperature","subitem_subject_scheme":"Other"},{"subitem_subject":"Fos","subitem_subject_scheme":"Other"},{"subitem_subject":"hyperalgesia; interleukin-1β (IL-1β)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"New functions of classical hormone α-melanophore-stimulating hormone","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"New functions of classical hormone α-melanophore-stimulating hormone"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3643","relation_version_is_last":true,"title":["New functions of classical hormone α-melanophore-stimulating hormone"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:34.923385+00:00"}