{"created":"2023-05-15T09:02:46.551911+00:00","id":3645,"links":{},"metadata":{"_buckets":{"deposit":"e7565611-5b5c-4198-a944-5a42dbf492a9"},"_deposit":{"created_by":3,"id":"3645","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3645"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003645","sets":["557:561:643"]},"author_link":["11836","11923","10780","11512","11921","11922","11502"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S226","bibliographicPageStart":"S219","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To clarify whether SEA can aff ect any changes of cellular signalling pathways in intestinal epithelial cells, weperformed experiments to see if SEA can modulate the intracellular signaling pathway in intestinal epithelial cells. Wedemonstrate here that SEA induces an increase in intracellular calcium（ ［Ca2+］i） in human intestinal epithelial cells andthe［ Ca2+］i is released from intracellular stores. SEA-induced increase of［ Ca2+］i was clearly inhibited by treatment witha nitric oxide synthase（ NOS） inhibitor, NG-monomethyl-L-arginine. Intestinal epithelial cells express endothelial NOS（eNOS） in resting cell condition, and express inducible NOS（ iNOS） after stimulating with tumor necrosis factor（ TNF）-α. TNF-α-pretreated cells showed a signifi cant increase in［ Ca2+］i that was also inhibited by the NOS inhibitor. Theseresults demonstrate that SEA induces an increase in intracellular Ca2+ concentration in human intestinal epithelial cells,and the expressions of both eNOS and iNOS could be responsible for the increase in intracellular Ca2+ concentration inthe cells induced by SEA. It is important to study the relationship of NOS expression, Ca2+ signal pathway and emesisfor understanding the mechanism of SEA-induced food poisoning.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S219-S226","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Physiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Radiology and Radiation Oncology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Veterinary Microbiology, Faculty of Agriculture, Iwate University"},{"subitem_text_value":"Department of Physiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hu, Dong-Liang"}],"nameIdentifiers":[{"nameIdentifier":"11502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suga, Yochiko"}],"nameIdentifiers":[{"nameIdentifier":"11923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Omoe, Katsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"11921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Abe, Yoshinao"}],"nameIdentifiers":[{"nameIdentifier":"10780","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shinagawa, Kunihiro"}],"nameIdentifiers":[{"nameIdentifier":"11922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakui, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"11836","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{"nameIdentifier":"11512","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S219.pdf","filesize":[{"value":"804.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S219.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3645/files/HirosakiMedJ_59_S219.pdf"},"version_id":"0f08c762-08a6-4eba-867f-b64a96c5766a"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Staphylococcal enterotoxin a modulates intracellular Ca^2+ signal pathway in human intestinal epithelial cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Staphylococcal enterotoxin a modulates intracellular Ca^2+ signal pathway in human intestinal epithelial cells"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3645","relation_version_is_last":true,"title":["Staphylococcal enterotoxin a modulates intracellular Ca^2+ signal pathway in human intestinal epithelial cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:58:47.873815+00:00"}