{"created":"2023-05-15T09:02:46.635479+00:00","id":3647,"links":{},"metadata":{"_buckets":{"deposit":"9270b139-7d46-4892-9756-f63eeb7766ea"},"_deposit":{"created_by":3,"id":"3647","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3647"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003647","sets":["557:561:643"]},"author_link":["11506","11512","11237"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S243","bibliographicPageStart":"S235","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Proteoglycans （PGs） are complex glycohydrates, which are widely distributed in connective tissues andon the cell surface of mammalian tissues. We investigated the effect of PG extracted from salmon cartilage oncytokine responses to stimulation with heat-killed Escherichia coli（ HKEC） in a mouse macrophage cell line, RAW264.7.PG exhibited the suppression of tumor necrosis factor（ TNF）-α production and enhancement of interleukin（ IL）-10production compared with chondroitin 4 sulfate（ C4S） and chondroitin 6 sulfate（ C6S）. PG, C4S and C6S suppressedHKEC-induced Toll-like receptor 4（ TLR4） and inducible nitric oxide synthase（ iNOS） expression dose-dependentlyand the PG showed the strongest suppressive effect among 3 compounds. Only PG dramatically up-regulated theexpression of signal transducers and activators of transcription 3（ STAT3） and the phosphorylation of STAT3 in mousemacrophages. Our results showed strong suppression of PG on infl ammatory response and suggested that the novelinteraction might exist between the extracellular matrix and immune system.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S235-S243","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Glycotechnology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sashinami, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"11506","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takagaki, Keiichi"}],"nameIdentifiers":[{"nameIdentifier":"11237","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{"nameIdentifier":"11512","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S235.pdf","filesize":[{"value":"327.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S235.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3647/files/HirosakiMedJ_59_S235.pdf"},"version_id":"951dbcb9-5bf0-4c5a-986c-1689eb3dcd0e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Proteoglycan","subitem_subject_scheme":"Other"},{"subitem_subject":"E. coli","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-10","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3647","relation_version_is_last":true,"title":["Salmon cartilage proteoglycan modulates cytokine responses to Escherichia coli in mouse macrophages"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:13:30.070745+00:00"}