@article{oai:hirosaki.repo.nii.ac.jp:00003648,
 author = {Hiraga, Hiroto and Sashinami, Hiroshi and Hu, Dong-Liang and Ishiguro, Yoh and Wakabayashi, Koichi and Munakata, Akihiro and Nakane, Akio},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Nov},
 note = {application/pdf, Dietary vitamin A is an essential precursor of tissue retinol, which participates in a variety of biological  processes including innate immunity. Functions of vitamin A mainly depend on retinoic acid（ RA）, principally all-trans- RA （atRA） and 9-cis-RA. We assessed whether atRA is benefi cial in host resistance against bacterial infections or  not. Vitamin A-defi cient（ VAD） mice were highly susceptible to infection with Listeria monocytogenes. Pre-treatment  with atRA enhanced host resistance against L. monocytogenes infection in both VAD and VAS mice. Interferon（ IFN） -γ production in atRA pre-treated VAS mice was not higher compared with the control VAD mice. The eff ect of atRA  was independent of T cells and B cells. The bactericidal activity in macrophages obtained from atRA pre-treated VAS  mice was almost the same level compared with the control VAS mice. Our results demonstrated that the treatment  with atRA is benefi cial for host resistance against L. monocytogenes infection in the early phase and suggested a new  therapeutic possibility of atRA in bacterial infections., 弘前医学. 59(Suppl.), 2007, p.S244-S252},
 pages = {S244--S252},
 title = {All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection},
 volume = {59},
 year = {2007}
}