{"created":"2023-05-15T09:02:46.677158+00:00","id":3648,"links":{},"metadata":{"_buckets":{"deposit":"d4b532b7-1d1e-4014-9bf7-0f77ad14fc79"},"_deposit":{"created_by":3,"id":"3648","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3648"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003648","sets":["557:561:643"]},"author_link":["11506","9403","11696","11512","11509","11502","11082"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S252","bibliographicPageStart":"S244","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":" Dietary vitamin A is an essential precursor of tissue retinol, which participates in a variety of biological  processes including innate immunity. Functions of vitamin A mainly depend on retinoic acid（ RA）, principally all-trans- RA （atRA） and 9-cis-RA. We assessed whether atRA is benefi cial in host resistance against bacterial infections or  not. Vitamin A-defi cient（ VAD） mice were highly susceptible to infection with Listeria monocytogenes. Pre-treatment  with atRA enhanced host resistance against L. monocytogenes infection in both VAD and VAS mice. Interferon（ IFN） -γ production in atRA pre-treated VAS mice was not higher compared with the control VAD mice. The eff ect of atRA  was independent of T cells and B cells. The bactericidal activity in macrophages obtained from atRA pre-treated VAS  mice was almost the same level compared with the control VAS mice. Our results demonstrated that the treatment  with atRA is benefi cial for host resistance against L. monocytogenes infection in the early phase and suggested a new  therapeutic possibility of atRA in bacterial infections. ","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S244-S252","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Molecular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hiraga, Hiroto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sashinami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Dong-Liang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiguro, Yoh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Munakata, Akihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S244.pdf","filesize":[{"value":"408.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S244.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3648/files/HirosakiMedJ_59_S244.pdf"},"version_id":"fb5a6015-d08c-44e0-b888-811782fb3e41"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3648","relation_version_is_last":true,"title":["All-trans-retinoic acid (atRA) increases host resistance to Listeria monocytogenes infection"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:06:21.684443+00:00"}