{"created":"2023-05-15T09:02:46.790501+00:00","id":3650,"links":{},"metadata":{"_buckets":{"deposit":"ccfe73a3-7b36-49c4-a6d2-5ee6b9c4ce0a"},"_deposit":{"created_by":3,"id":"3650","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3650"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003650","sets":["557:561:643"]},"author_link":["11937"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S261","bibliographicPageStart":"S253","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Distinctive sex diff erences in reproductive behavior and physiology have been attributed not to diff erences\nin hormones gonad secretes in each sex but differences in particular brain structures. Interestingly enough, brain\nsex difference is determined mostly by gonadal hormones during ontogeny independent of genetic sex. In many\nlaboratory mammals, brain sex can be manipulated at a particular stage of ontogeny called critical period for brain sex\ndiff erentiation, by endocrine treatments. Thus, neonatal orchidectomy or administration of gonadal hormones to female\npups reverses brain sex phenotype which culminates in sex-specifi c functions. The early, transient exposure to gonadal\nhormones or its absence leaves indelible marks on brain phenotype. This organizing action of gonadal hormones,\ncombined with activational action of the hormones after puberty, accomplishes sex specific functions. Brain would\nundergo sex diff erentiation through neurogenesis, migration, or survival in addition to regulation of ion channels and\nother functional molecule. Two distinct structures, the sexually dimorphic nucleus of the preoptic area, which is larger\nin male rats than in males and the anteroventral periventricular nucleus, which furnish opposite characteristics, will\nprovide good opportunity to understand the mechanism of brain sex diff erentiation.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S253-S261","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Physiology, Nippon Medical School"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakuma, Yasuo"}],"nameIdentifiers":[{"nameIdentifier":"11937","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S253.pdf","filesize":[{"value":"2.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S253.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3650/files/HirosakiMedJ_59_S253.pdf"},"version_id":"859fc298-05f8-4a54-b4cc-890caa960a07"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mechanisms for brain sex diff erentiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanisms for brain sex diff erentiation"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-09-18"},"publish_date":"2009-09-18","publish_status":"0","recid":"3650","relation_version_is_last":true,"title":["Mechanisms for brain sex diff erentiation"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-05-16T06:42:29.642973+00:00"}