{"created":"2023-05-15T09:02:46.856264+00:00","id":3651,"links":{},"metadata":{"_buckets":{"deposit":"27f6fe50-0ec5-455f-a112-765f86078f66"},"_deposit":{"created_by":3,"id":"3651","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3651"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003651","sets":["557:561:643"]},"author_link":["9620","11941","9624","9629","11939"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-11-29","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Suppl.","bibliographicPageEnd":"S287","bibliographicPageStart":"S278","bibliographicVolumeNumber":"59","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Our primary concern in this review is to give possible explanations and pose new questions on the phenomena\nconcerning effects of neonatal estrogen exposure on the development and functions of reproductive organs and immune\nmechanisms particularly in male animals, in the light of new findings and cencepts. At first, our own experimental results\non the pathological changes in the epididymis and testis in neonatally estrogenized mice have been presented. The results\nof our first experiment showed that neonatal single injection of 10 flg of estradiol benzoate induced marked inflammatory\nchanges in the epididymis and testis, in which the initial pathological change occurred concomitantly with the appearance\nof sperms in the epididymal duct. The second experiment showed that such epididymo-testicular changes did not occur\nwhen the testis was removed or neonatal estrogen was followed by testosterone. From these results, a possibility was\nsuggested that a hormone-related autoimmune mechanism might participate in such changes. Relating to these, various\nreports concerning effects of neonatal estrogen treatment, either alone or with concommitent treatment with androgen.\non the development and functions of reproductive organs and immune mechanisms in the adolescent or adult have been\nreviewed. In addition, advances in the related areas, such as estrogen-related mechanisms in the development and\nfunctions of reproductive organs and immune mechanisms including autoimmune disease mechanisms. gender differences\nand the role of CD25+ CD4+ T lymphocytes have also been reviewed briefly.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 59(Suppl.), 2007, p.S278-287","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9620","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カチ, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11941","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カチ, ヒトミ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9624","nameIdentifierScheme":"WEKO"}],"names":[{"name":"加地, 隆"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.1","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Anatomical Science, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kachi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"9629","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kachi, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"11939","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_59_S278.pdf","filesize":[{"value":"168.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_59_S278.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3651/files/HirosakiMedJ_59_S278.pdf"},"version_id":"18cc1b5d-89b3-47ed-931c-ceb5d9d891c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"perinatal sex steroids","subitem_subject_scheme":"Other"},{"subitem_subject":"development of reproductive organs","subitem_subject_scheme":"Other"},{"subitem_subject":"epididymo-testicular inflammatory change","subitem_subject_scheme":"Other"},{"subitem_subject":"autoimmune disease","subitem_subject_scheme":"Other"},{"subitem_subject":"regulatory T lymphocyte","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited"}]},"item_type_id":"3","owner":"3","path":["643"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-05-26"},"publish_date":"2009-05-26","publish_status":"0","recid":"3651","relation_version_is_last":true,"title":["Experimental Studies on Morphological Changes of the Epididymis and Testis in Neonatally Estrogenized Mice Revisited"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T11:09:03.030812+00:00"}