{"created":"2023-05-15T09:02:47.068227+00:00","id":3655,"links":{},"metadata":{"_buckets":{"deposit":"2a84fe38-9633-43fc-90a9-49617f67f1a3"},"_deposit":{"created_by":3,"id":"3655","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3655"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003655","sets":["557:561:644"]},"author_link":["11155","11330","11951","11956","11945","11950","11163","11949","11954","11328","11948","11957","11960","11958","11326","11946","11947","11961","11952","11147"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"塩基性へアケラチン遺伝子群を欠失する弘前ヘアレスラットの毛包の性質：毛髄質の拡大と毛小皮の欠損，退行期の延長"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"エンキセイ エ アケラチン イデンシグン オ ケッシツスル ヒロサキ エ アレスラット ノ ケガワ ノ セイシツ : モウズイシツ ノ カクダイ ト モウショウヒ ノ ケッソン タイコウキ ノ エンチョウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"11","bibliographicPageStart":"1","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The Hirosaki hairless rat （HHR） is a mutant strain spontaneously derived from the Sprague-Dawley rat\n（SDR） and its inheritance is autosomal recessive. Our recent study has revealed that an 80-kb genomic DNA on 7q36\ncontaining basic hair keratin genes, Kb21, Kb23, Kb26 and Krt2-25, is deleted in HHR. To characterize hair follicles in\nHHR, progression of hair cycle and expression profi les of basic hair keratins were immunohistochemically studied and\ncompared with those of SDR. The HHR exhibited sparse hairs and their twisted hairs were shorter than SDR hairs.\nHHR hair follicles entered the catagen phase earlier than SDR and massive destruction of HHR hair follicles and\ninfi ltration of infl ammatory cells occurred in the catagen phase. In HHR the hair medulla was enlarged and the inner\nroot sheath was thinned while the hair cortex was formed where Kb25 was expressed. In SDR Kb25 was expressed\nin the hair matrix and medulla. Electron microscopy indicated loss of the cuticle in HHR. These results suggest that\nhypotrichosis of HHR is due to the deletion of hair keratin genes and expression of a keratin fusion gene. Thus, HHR\nseems to be a useful model to examine the role of hair keratins in the hair follicle formation.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.1-11","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11950","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アキタ, ミキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11951","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナナシマ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11952","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマダ, トシユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"11954","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シミズ, タケシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11328","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツチダ, シゲキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11956","nameIdentifierScheme":"WEKO"}],"names":[{"name":"秋田, 美季"}]},{"nameIdentifiers":[{"nameIdentifier":"11957","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"416","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/416_ja.html"}],"names":[{"name":"七島, 直樹"}]},{"nameIdentifiers":[{"nameIdentifier":"11958","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山田, 俊幸"}]},{"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 創"}]},{"nameIdentifiers":[{"nameIdentifier":"11960","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"200","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/200_ja.html"}],"names":[{"name":"清水, 武史"}]},{"nameIdentifiers":[{"nameIdentifier":"11961","nameIdentifierScheme":"WEKO"}],"names":[{"name":"范, 洋"}]},{"nameIdentifiers":[{"nameIdentifier":"11326","nameIdentifierScheme":"WEKO"}],"names":[{"name":"土田, 成紀"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Akita, Miki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nanashima, Naoki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamada, Toshiyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Shimizu, Takeshi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Fan, Yang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tsuchida, Shigeki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_1.pdf","filesize":[{"value":"816.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_1.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3655/files/HirosakiMedJ_60_1-4_1.pdf"},"version_id":"03c0e329-fd3b-4dbc-9096-063ee7026c39"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"gene deletion","subitem_subject_scheme":"Other"},{"subitem_subject":"hair cycle","subitem_subject_scheme":"Other"},{"subitem_subject":"hair follicle","subitem_subject_scheme":"Other"},{"subitem_subject":"hypotrichosis","subitem_subject_scheme":"Other"},{"subitem_subject":"keratin","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子欠失","subitem_subject_scheme":"Other"},{"subitem_subject":"毛周期","subitem_subject_scheme":"Other"},{"subitem_subject":"毛包","subitem_subject_scheme":"Other"},{"subitem_subject":"乏毛症","subitem_subject_scheme":"Other"},{"subitem_subject":"ケラチン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-08"},"publish_date":"2009-04-08","publish_status":"0","recid":"3655","relation_version_is_last":true,"title":["Characterization of Hair Follicles in Hirosaki Hairless Rats with Deletion of Basic Hair Keratin Genes. Enlarged Medulla, Loss of Cuticle and Long Catagen"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:46:12.491287+00:00"}