{"created":"2023-05-15T09:02:47.153342+00:00","id":3657,"links":{},"metadata":{"_buckets":{"deposit":"c0016705-a41e-4193-8f7f-32d9079c7346"},"_deposit":{"created_by":3,"id":"3657","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3657"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003657","sets":["557:561:644"]},"author_link":["12736","11979","11977","11991","11992","11982","11980","12747","11978","11875","11984","11976","11985","11987","11990","11983","11988","11989","11994","11975","11981"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Coupling factor 6 過剰発現マウスの作成と表現型の解析"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Coupling factor 6 カジョウ ハツゲン マウス ノ サクセイ ト ヒョウゲンガタ ノ カイセキ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"26","bibliographicPageStart":"18","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We showed that endogenous prostacyclin inhibitor coupling factor 6 （CF6） is released from vascular\nendothelial cells and its release is stimulated by tumor necrosis factor-α, which is related to congestive heart failure\n（CHF）. We also showed that CF6 increases the gene expression related to CHF. To investigate the role of CF6 in\nthe genesis of CHF, we generated CF6-overexpressing transgenic（ TG） mice, and characterized the phenotype. DNA\nfragment consisting of human elongation factor 1α promoter, and human calcitonin/CF6 fused gene was injected into\nthe embryo of C57BL/6J mouse, and homozygous TG mice were generated. In TG mice, CF6 gene was overexpressed\nby two fold in overall tissues compared with wild type（ WT） mice. Under normal salt diet, blood pressure, heart rate,\nand the expression of energy metabolism-related genes were similar between TG and WT mice. When the mice were\nfed with 8% -salt diet for 35 weeks, the mortality of TG mice was higher than that of WT mice（ survival rate; 50% in\nTG versus 92% in WT, p<0.05 by log-rank test）. This preliminary report indicates that further examination, especially\nanalysis of the cardiac function, is needed to clarify the cause of high mortality of TG mice under high salt intake.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.18-26","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11981","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アシタテ, トシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11983","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タナカ, マコト"}]},{"nameIdentifiers":[{"nameIdentifier":"11984","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マゴタ, コウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11985","nameIdentifierScheme":"WEKO"}],"names":[{"name":"エチゼン, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12736","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トミタ, ヒロフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11988","nameIdentifierScheme":"WEKO"}],"names":[{"name":"芦立, 俊宗"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"11990","nameIdentifierScheme":"WEKO"}],"names":[{"name":"田中, 真実"}]},{"nameIdentifiers":[{"nameIdentifier":"11991","nameIdentifierScheme":"WEKO"}],"names":[{"name":"孫田, 浩二"}]},{"nameIdentifiers":[{"nameIdentifier":"11992","nameIdentifierScheme":"WEKO"}],"names":[{"name":"越前, 崇"}]},{"nameIdentifiers":[{"nameIdentifier":"12747","nameIdentifierScheme":"WEKO"}],"names":[{"name":"富田, 泰史"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.4","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Asubio Pharma Co., Ltd., Biomedical Center, Biopharma Research Department, Biotechnology Group"},{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University, Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ashitate, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanaka, Makoto"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Magota, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Echizen, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_18.pdf","filesize":[{"value":"281.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_18.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3657/files/HirosakiMedJ_60_1-4_18.pdf"},"version_id":"15300c71-d9e6-4fb1-854b-a7bf25b42852"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"coupling factor 6","subitem_subject_scheme":"Other"},{"subitem_subject":"transgenic mice","subitem_subject_scheme":"Other"},{"subitem_subject":"congestive heart failure","subitem_subject_scheme":"Other"},{"subitem_subject":"enerugy metabolism","subitem_subject_scheme":"Other"},{"subitem_subject":"high salt loading","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子組み換えマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"うっ血性心不全","subitem_subject_scheme":"Other"},{"subitem_subject":"エネルギー代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"食塩負荷","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Generation and Characterization of Coupling Factor 6-Overexpressing Transgenic Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Generation and Characterization of Coupling Factor 6-Overexpressing Transgenic Mice"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-08"},"publish_date":"2009-04-08","publish_status":"0","recid":"3657","relation_version_is_last":true,"title":["Generation and Characterization of Coupling Factor 6-Overexpressing Transgenic Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:42:35.228929+00:00"}