{"created":"2023-05-15T09:02:47.237160+00:00","id":3659,"links":{},"metadata":{"_buckets":{"deposit":"388b56b2-7815-41a1-abc1-60aae7ec87f3"},"_deposit":{"created_by":3,"id":"3659","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3659"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003659","sets":["557:561:644"]},"author_link":["12024","11987","12012","11875","12014","12010","11982","11989","11976","12020","11994","12017","12011","12015","12019"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"低酸素による心筋細胞Insulin-like growth factor-1 遺伝子発現亢進の役割 : 心保護作用の機序について"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"テイサンソ ニヨル シンキン サイボウ Insulin-like growth factor-1 イデンシ ハツゲン コウシン ノ ヤクワリ : シン ホゴ サヨウ ノ キジョ ニツイテ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"44","bibliographicPageStart":"36","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Insulin-like growth factor （IGF）-1 is known to exert benefi cial eff ects on the heart, but its source and\nfunction under hypoxia are unknown. We investigated the eff ect of hypoxia on IGF-1 expression and its role in the\nregeneration in the heart. Cardiac myocytes and fi broblasts obtained from neonate mice heart were cultured and\nexposed to hypoxia. mRNA of IGF-1, IGF-binding protein 3 （IGFBP3）, and vascular endothelial growth factor-A\n（VEGF-A） was measured by real-time PCR. In cardiac myocytes, IGF-1 mRNA was increased by 3.5±1.1 fold at 3\nhours after hypoxia concomitantly with the increase in IGFBP3 and VEGF-A mRNA, and returned to the baseline at\n24 hours. In contrast, IGF-1 mRNA in cardiac fi broblasts was unchanged by hypoxia, although VEGF-A mRNA was\nincreased. To investigate the role of IGF-1 in the heart regeneration, we measured the gene expressions of stromal\ncell-derived factor-1（ SDF-1）, its receptor CXCR4, and matrix metalloproteinase（ MMP）-14 related to cell homing. In\ncardiac myocytes, SDF-1 and MMP-14 mRNA were increased at 3 hours after hypoxia and tended to be positively\ncorrelated with IGF-1 mRNA. These suggest that hypoxia increases IGF-1 expression in cardiac myocytes, and this\nendogenous IGF-1 may exert benefi cial eff ects on regeneration in the heart.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.36-44","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12012","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カトウ, チサト"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12014","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シブタニ, シュウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12015","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, ケンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12017","nameIdentifierScheme":"WEKO"}],"names":[{"name":"加藤, 千里"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"12019","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渋谷, 修司"}]},{"nameIdentifiers":[{"nameIdentifier":"12020","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 賢二"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kato, Chisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibutani, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_36.pdf","filesize":[{"value":"340.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_36.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3659/files/HirosakiMedJ_60_1-4_36.pdf"},"version_id":"eb793bd1-4573-4614-9955-8c33e36b27f0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"cardiac myocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac fibroblasts","subitem_subject_scheme":"Other"},{"subitem_subject":"insulin-like growth factor-1","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-08"},"publish_date":"2009-04-08","publish_status":"0","recid":"3659","relation_version_is_last":true,"title":["Upregulation of Insulin-Like Growth Factor-1 Gene Expression in Cardiac Myocytes by Hypoxia : Mechanism for Its Cardioprotective Effect"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:26:25.418610+00:00"}