@article{oai:hirosaki.repo.nii.ac.jp:00003660,
 author = {Horiuchi, Daisuke and Osanai, Tomohiro and Echizen, Takashi and Ashitate, Toshihiro and Kato, Chisato and Yokoyama, Hiroaki and Hanada, Kenji and Shibutani, Shuji and Itoh, Taihei and Okumura, Ken},
 issue = {1/2/3/4},
 journal = {弘前医学},
 month = {Mar},
 note = {application/pdf, Structural remodeling occurs in diverse heart diseases and affects their clinical courses. We reported
that amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model.
As a mechanism for amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrix
metalloproteinase（ MMP） activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a rat
myocardial infarction model created by left coronary artery（ LCA） ligation. Adult Sprague-Dawley rats were divided
into sham-operated （Sham）, sham-operated with amiodarone （Sham+AMD）, LCA-ligated without amiodarone （MI）
and LCA-ligated with amiodarone rats （MI+AMD）. Amiodarone （20 mg/kg/day） was administered for 2 weeks
before and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity was
measured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased in
MI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats （P=NS）.
As compared with Sham, MMP-2 activity was increased in MI （P<0.01）, but not in MI+AMD （P=NS versus Sham;
P<0.05 versus MI）. MMP-2 activity was not increased in Sham+AMD（ P=NS）. Thus, amiodarone exerts an inhibitory
eff ect on MMP activity. This may be related to the improvement left ventricular function in MI rats., 弘前医学. 60(1/2/3/4), 2009, p.45-53},
 pages = {45--53},
 title = {Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model},
 volume = {60},
 year = {2009}
}