{"created":"2023-05-15T09:02:47.280044+00:00","id":3660,"links":{},"metadata":{"_buckets":{"deposit":"b01bc6e3-5c52-4884-a3de-292b8697fa45"},"_deposit":{"created_by":3,"id":"3660","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3660"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003660","sets":["557:561:644"]},"author_link":["12024","12044","11979","11992","11982","12011","12022","12019","12025","11875","12010","12028","11976","12017","12047","12014","12037","11985","11987","12039","12020","12034","12029","12012","11988","11989","11994","11975","11981","12015"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アミオダロンのマトリックスメタロプロテイナーゼ-2 活性に対する作用 ：ラット心筋梗塞モデルでの検討"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"アミオダロン ノ マトリックス メタロプロテイナーゼ -2 カッセイ ニ タイスル サヨウ : ラット シンキン コウソク モデル デノ ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"53","bibliographicPageStart":"45","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Structural remodeling occurs in diverse heart diseases and affects their clinical courses. We reported\nthat amiodarone suppresses both electrical and structural remodeling in a canine persistent atrial fi brillation model.\nAs a mechanism for amiodarone’s effect on structural remodeling, we suggested its inhibitory effect on matrix\nmetalloproteinase（ MMP） activity. To elucidate it, we investigated the eff ect of amiodarone on MMP activity in a rat\nmyocardial infarction model created by left coronary artery（ LCA） ligation. Adult Sprague-Dawley rats were divided\ninto sham-operated （Sham）, sham-operated with amiodarone （Sham+AMD）, LCA-ligated without amiodarone （MI）\nand LCA-ligated with amiodarone rats （MI+AMD）. Amiodarone （20 mg/kg/day） was administered for 2 weeks\nbefore and for 4 weeks after operation. The hearts were excised at 4 weeks after operation. MMP-2 activity was\nmeasured by gelatin zymography. At 4 weeks after surgery, left ventricular fractional shortening was decreased in\nMI but not in MI+AMD rats. There was no diff erence in the infarct size between MI and MI+AMD rats （P=NS）.\nAs compared with Sham, MMP-2 activity was increased in MI （P<0.01）, but not in MI+AMD （P=NS versus Sham;\nP<0.05 versus MI）. MMP-2 activity was not increased in Sham+AMD（ P=NS）. Thus, amiodarone exerts an inhibitory\neff ect on MMP activity. This may be related to the improvement left ventricular function in MI rats.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.45-53","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12029","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホリウチ, ダイスケ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"11985","nameIdentifierScheme":"WEKO"}],"names":[{"name":"エチゼン, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11981","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アシタテ, トシヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12012","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カトウ, チサト"}]},{"nameIdentifiers":[{"nameIdentifier":"12034","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨコヤマ, ヒロアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12015","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, ケンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12014","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シブタニ, シュウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12037","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, タイヘイ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12039","nameIdentifierScheme":"WEKO"}],"names":[{"name":"堀内, 大輔"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"11992","nameIdentifierScheme":"WEKO"}],"names":[{"name":"越前, 崇"}]},{"nameIdentifiers":[{"nameIdentifier":"11988","nameIdentifierScheme":"WEKO"}],"names":[{"name":"芦立, 俊宗"}]},{"nameIdentifiers":[{"nameIdentifier":"12017","nameIdentifierScheme":"WEKO"}],"names":[{"name":"加藤, 千里"}]},{"nameIdentifiers":[{"nameIdentifier":"12044","nameIdentifierScheme":"WEKO"}],"names":[{"name":"横山, 公章"}]},{"nameIdentifiers":[{"nameIdentifier":"12020","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 賢二"}]},{"nameIdentifiers":[{"nameIdentifier":"12019","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渋谷, 修司"}]},{"nameIdentifiers":[{"nameIdentifier":"12047","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 太平"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.23","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Horiuchi, Daisuke"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Echizen, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ashitate, Toshihiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kato, Chisato"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yokoyama, Hiroaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibutani, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Taihei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_45.pdf","filesize":[{"value":"415.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_45.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3660/files/HirosakiMedJ_60_1-4_45.pdf"},"version_id":"fc88a719-3322-4c84-9033-3fee9a83bd54"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"structural remodeling","subitem_subject_scheme":"Other"},{"subitem_subject":"amiodarone","subitem_subject_scheme":"Other"},{"subitem_subject":"matrix metalloproteinases","subitem_subject_scheme":"Other"},{"subitem_subject":"myocardial infarction","subitem_subject_scheme":"Other"},{"subitem_subject":"構造的モデリング","subitem_subject_scheme":"Other"},{"subitem_subject":"アミオダロン","subitem_subject_scheme":"Other"},{"subitem_subject":"マトリックスメタロプロテイナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"心筋梗塞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-08"},"publish_date":"2009-04-08","publish_status":"0","recid":"3660","relation_version_is_last":true,"title":["Amiodarone Attenuates the Upregulated Matrix Metalloproteinase-2 Activity in a Rat Myocardial Infarction Model"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:43:15.611757+00:00"}