{"created":"2023-05-15T09:02:47.322037+00:00","id":3661,"links":{},"metadata":{"_buckets":{"deposit":"f2b98469-334d-4fe2-b16a-d2339a2de3fd"},"_deposit":{"created_by":3,"id":"3661","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3661"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003661","sets":["557:561:644"]},"author_link":["11114","12067","11138","12058","11120","12065","12066","11123","11128","11121","11131","12060","12052","12059","12051","12049","12063","12057","12054","12053","11129","12055","11137","12068"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"膵ランゲルハンス島に引き起こされる低酸素性機能障害の経時的変化とメカニズム"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"スイランゲルハンストウ ニ ヒキオコサレル テイサンソセイ キノウ ショウガイ ノ ケイジテキ ヘンカ ト メカニズム"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"62","bibliographicPageStart":"54","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The aim of this study was to determine the time course and mechanism of hypoxia-induced pancreaticislet dysfunction. Islets isolated from Sprague Dawley rats were cultured in 1％ O2（ hypoxia）. Glucose stimulatedinsulin secretion（ GSIS） was then examined for islets in either static or perifused cultures, followed by an evaluation ofmitochondrial activity and islet cell death. Additionally, we examined the eff ect of culturing previously hypoxic islets foran additional 24 h under normoxia to determine whether the hypoxic eff ects were reversible and to assess the eff ects ofre-oxygenation on GSIS. In the static islet culture, insulin secretion declined signifi cantly after 24 h. In perifused islets,the area under the curve（ AUC） of fi rst-phase GSIS declined signifi cantly after 6 h, while the AUC of second-phase GSISdecreased signifi cantly after 12 h. Mitochondrial activity dropped markedly after 48 h, but cell death assays revealedthat apoptosis did not increase in the time period from 6 h to 48 h. However, necrosis increased signifi cantly after 24 h.In the re-oxygenation study, the return to normoxia signifi cantly worsened the decline in GSIS. In conclusion, exposureto hypoxia fi rst causes functional disorder in the islets, followed by cell death due to necrosis rather than apoptosis.Furthermore, re-oxygenation aggravated islet dysfunction.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.54-62","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12055","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トモツネ, ケン"}]},{"nameIdentifiers":[{"nameIdentifier":"11128","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オガワ, ヨシジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12057","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハセガワ, ノリユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12058","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クドウ, タカノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"12059","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナラオカ, マキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12060","nameIdentifierScheme":"WEKO"}],"names":[{"name":"チカザワ, シンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11123","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タマサワ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11129","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スダ, トシヒロ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12063","nameIdentifierScheme":"WEKO"}],"names":[{"name":"友常, 健"}]},{"nameIdentifiers":[{"nameIdentifier":"11120","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小川, 吉司"}]},{"nameIdentifiers":[{"nameIdentifier":"12065","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長谷川, 範幸"}]},{"nameIdentifiers":[{"nameIdentifier":"12066","nameIdentifierScheme":"WEKO"}],"names":[{"name":"工藤, 貴徳"}]},{"nameIdentifiers":[{"nameIdentifier":"12067","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奈良岡, 真紀"}]},{"nameIdentifiers":[{"nameIdentifier":"12068","nameIdentifierScheme":"WEKO"}],"names":[{"name":"近澤, 真司"}]},{"nameIdentifiers":[{"nameIdentifier":"11114","nameIdentifierScheme":"WEKO"}],"names":[{"name":"玉澤, 直樹"}]},{"nameIdentifiers":[{"nameIdentifier":"11121","nameIdentifierScheme":"WEKO"}],"names":[{"name":"須田, 俊宏"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.4","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Diabetes Unit, Aomori Prefectural Central Hospital"},{"subitem_text_value":"Department of Internal Medicine, Itayanagi Central Hospital"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Endocrinology and Metabolism, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Tomotsune, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ogawa, Yoshiji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Noriyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kudo, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Naraoka, Maki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chikazawa, Shinji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tamasawa, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Suda, Toshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_54.pdf","filesize":[{"value":"394.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_54.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3661/files/HirosakiMedJ_60_1-4_54.pdf"},"version_id":"c77120df-94cb-4f2b-9f68-d07e4ad19a4e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Islet transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"islet cell death","subitem_subject_scheme":"Other"},{"subitem_subject":"mitochondrial activity","subitem_subject_scheme":"Other"},{"subitem_subject":"hypoxia","subitem_subject_scheme":"Other"},{"subitem_subject":"re-oxygenation","subitem_subject_scheme":"Other"},{"subitem_subject":"膵島移植","subitem_subject_scheme":"Other"},{"subitem_subject":"膵島細胞死","subitem_subject_scheme":"Other"},{"subitem_subject":"ミトコンドリア活性","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"},{"subitem_subject":"再酸素化","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Hypoxia induces Dysfunction and Cell Death of the Rat Pancreatic Isle","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Hypoxia induces Dysfunction and Cell Death of the Rat Pancreatic Isle"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-08"},"publish_date":"2009-04-08","publish_status":"0","recid":"3661","relation_version_is_last":true,"title":["Hypoxia induces Dysfunction and Cell Death of the Rat Pancreatic Isle"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:22:56.990109+00:00"}