{"created":"2023-05-15T09:02:47.449417+00:00","id":3664,"links":{},"metadata":{"_buckets":{"deposit":"7f245141-6443-46fc-8c64-6da1e72a4493"},"_deposit":{"created_by":3,"id":"3664","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3664"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003664","sets":["557:561:644"]},"author_link":["12111","12121","11982","12114","12105","12117","12119","12110","12116","11875","11976","12106","12107","11987","12112","11989","11994","12118","12109","12104","12108"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"高血圧自然発症ラットの内皮依存性過分極因子反応におけるカルシウム活性化カリウムチャネルの障害"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コウケツアツ シゼン ハッショウ ラット ノ ナイヒ イゾンセイ カブン キョクインシ ハンノウ ニオケル カルシウム カッセイカ カリウム チャネル ノ ショウガイ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1/2/3/4","bibliographicPageEnd":"95","bibliographicPageStart":"86","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"To examine the effect of chronic hypertension on endothelium-derived hyperpolarizing factor（ EDHF）\nresponses, the hearts of Wistar-Kyoto rats（ WKY） and spontaneously hypertensive rats（ SHR） were isolated and\nperfused using Langendorff system with constant perfusion pressure. Bradykinin increased coronary fl ow（ CF） dosedependently\nand this was not aff ected by NG-nitro-L-arginine methyl ester or indomethacin, indicating that bradykinin’s\neff ect on CF was not mediated by nitric oxide or prostacyclin but by EDHF. Bradykinin-induced CF increase was smaller\nin SHR than in WKY. Tetrabutylammonium（ a non-specific KCa channel blocker） abolished bradykinin-induced CF\nincrease in both rats. 1-Ethyl-2-benzimedazolinone（ 1-EBIO, an agonist of intermediate conductance KCa channel）-induced\nincrease in CF was smaller in SHR than in WKY. 1,3-Dihydro-1-[2-hydroxy-5（- trifl uoromethyl） phenyl]-5（- trifl uoromethyl）\n-2H-benzimidazol-2-one（ NS1619, an agonist of large conductance KCa channel）-induced increase in CF did not differ\nbetween SHR and WKY. In early stage of hypertension, there was no signifi cant diff erence between SHR and WKY in\nbradykinin- and 1-EBIO-induced increases in CF. In conclusion, EDHF response in coronary microcirculation is impaired\nin SHR due to dysfunction of intermediate-conductance calcium-activated potassium channels.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 60(1/2/3/4), 2009, p.86-95","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12109","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハセガワ, カズシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12110","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オイカワ, コウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"12111","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, イッコウ"}]},{"nameIdentifiers":[{"nameIdentifier":"12112","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシザカ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12114","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モトムラ, シゲル"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12116","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長谷川, 一志"}]},{"nameIdentifiers":[{"nameIdentifier":"12117","nameIdentifierScheme":"WEKO"}],"names":[{"name":"及川, 広一"}]},{"nameIdentifiers":[{"nameIdentifier":"12118","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 一弘"}]},{"nameIdentifiers":[{"nameIdentifier":"12119","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石坂, 浩"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"12121","nameIdentifierScheme":"WEKO"}],"names":[{"name":"元村, 成"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.2","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pharmacology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hasegawa, Kazushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Oikawa, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshida, Ikko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaka, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motomura, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_60_1-4_86.pdf","filesize":[{"value":"529.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_60_1-4_86.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3664/files/HirosakiMedJ_60_1-4_86.pdf"},"version_id":"748e2a85-65e1-4589-b3d6-3e89ed19b662"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Endothelium-derived hyperpolarizing factor (EDHF)","subitem_subject_scheme":"Other"},{"subitem_subject":"Coronary microcirculation","subitem_subject_scheme":"Other"},{"subitem_subject":"Calcium-activated potassium channel","subitem_subject_scheme":"Other"},{"subitem_subject":"Hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"内皮依存性過分極因子","subitem_subject_scheme":"Other"},{"subitem_subject":"冠微小循環","subitem_subject_scheme":"Other"},{"subitem_subject":"カルシウム活性化カリウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats"}]},"item_type_id":"3","owner":"3","path":["644"],"pubdate":{"attribute_name":"公開日","attribute_value":"2009-04-09"},"publish_date":"2009-04-09","publish_status":"0","recid":"3664","relation_version_is_last":true,"title":["Impairment of Calcium-Activated Potassium Channels in Endothelium-Derived Hyperpolarizing Factor Responses in Spontaneously Hypertensive Rats"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:42:59.679868+00:00"}