{"created":"2023-05-15T09:02:47.597316+00:00","id":3667,"links":{},"metadata":{"_buckets":{"deposit":"d01e200c-bfbe-4cf9-ba48-a778a5abcf85"},"_deposit":{"created_by":3,"id":"3667","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3667"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003667","sets":["557:561:645"]},"author_link":["12111","12121","11982","12114","12119","12116","11875","11976","12106","12107","11987","12165","12112","12158","11989","11994","12154","12118","12109","12104","12108"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"アデノシン誘発性冠抵抗血管の拡張は２型糖尿病ラットで障害されている : ATP 感受性Kチャネルと一酸化窒素の役割"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"アデノシン ユウハツセイ カンテイコウ ケッカン ノ カクチョウ ワ ニガタ トウニョウビョウ ラット デ ショウガイ サレテイル ATP カンジュセイ Kチャネル ト イッサンカ チッソ ノ ヤクワリ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"18","bibliographicPageStart":"8","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives The purpose of this study was to test the hypothesis that adenosine-induced coronary\nmicrovascular dilation is blunted in the animals with diabetes mellitus（ DM） through the impairment of KATP channel\nfunction.\n　 Background Adenosine-induced coronary vasodilation is demonstrated to be mediated by activation of ATPsensitive\npotassium（ KATP） channels and nitric oxide（ NO）.\n　Methods The hearts of Otsuka Long-Evans Tokushima fatty rats （OLETF, type 2 DM rats）, and control Long-\nEvans Tokushima fatty rats（ LETO） at the ages of 32 and 8 weeks were perfused using a Langendorff system with\nconstant perfusion pressure （80 mmHg）. Changes in coronary fl ow to adenosine, pinacidil and sodium nitroprusside\n（SNP） were examined before and after administration of glibenclamide（ 10-7 M）, or NG-nitro-L-arginine methyl ester\n（L-NAME, 10-4 M）.\n　 Results At the age of 32 weeks, adenosine- and pinacidil-induced increases in coronary fl ow were blunted in OLETF\nas compared with those in LETO （both p<0.05）. Glibenclamide attenuated adenosine-induced increase in coronary\nfl ow in LETO （p<0.05）, but not in OLETF. In contrast, L-NAME attenuated adenosine-induced increase in coronary\nflow in OLETF （p<0.05）, but not in LETO. SNP-induced increases in coronary flow in LETO and OLETF were\ncomparable and were not aff ected by glibenclamide. In 8-week-old OLETF and LETO, no diff erence was observed in\nadenosine-, pinacidil- and SNP-induced increases in coronary fl ow between OLETF and LETO.\n　Conclusions In this type 2 DM model, KATP channel function in coronary microcirculation is impaired. Adenosineinduced\nincrease in coronary fl ow is mediated mainly by NO mechanism.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(1), 2010, p.8-18","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12111","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, イッコウ"}]},{"nameIdentifiers":[{"nameIdentifier":"12112","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシザカ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12109","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハセガワ, カズシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, キヨヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12114","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モトムラ, シゲル"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12118","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 一弘"}]},{"nameIdentifiers":[{"nameIdentifier":"12119","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石坂, 浩"}]},{"nameIdentifiers":[{"nameIdentifier":"12116","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長谷川, 一志"}]},{"nameIdentifiers":[{"nameIdentifier":"12165","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 清彦"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"12121","nameIdentifierScheme":"WEKO"}],"names":[{"name":"元村, 成"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.1","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pharmacology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Cardiology, Respiratory Medicine and Nephrology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Ikko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishizaka, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hasegawa, Kazushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Satoh, Kiyohiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Motomura, Shigeru"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61(1)_8.pdf","filesize":[{"value":"403.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61(1)_8.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3667/files/HirosakiMedJ_61(1)_8.pdf"},"version_id":"35819d78-3f05-408f-a6db-fee07a1337da"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"adenosine","subitem_subject_scheme":"Other"},{"subitem_subject":"diabetes mellitus","subitem_subject_scheme":"Other"},{"subitem_subject":"microcirculation","subitem_subject_scheme":"Other"},{"subitem_subject":"nitric oxide","subitem_subject_scheme":"Other"},{"subitem_subject":"アデノシン","subitem_subject_scheme":"Other"},{"subitem_subject":"糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"微小循環","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化炭素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide"}]},"item_type_id":"3","owner":"3","path":["645"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-29"},"publish_date":"2010-03-29","publish_status":"0","recid":"3667","relation_version_is_last":true,"title":["Adenosine-Induced Dilation of Coronary Resistance Vessels Is Impaired in Rats with Type 2 Diabetes Mellitus: Possible Role of ATP-Sensitive Potassium Channels and Nitric Oxide"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:43:07.352734+00:00"}