{"created":"2023-05-15T09:02:47.791134+00:00","id":3670,"links":{},"metadata":{"_buckets":{"deposit":"b0a88318-c6a1-4da0-9cd1-8347caaabc4c"},"_deposit":{"created_by":3,"id":"3670","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3670"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003670","sets":["557:561:645"]},"author_link":["12207","12199","12209","12197","12196","12204","12205","12208","12201","12203","12200","12202","12198","12206","12195"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス同種異系臍帯血移植による免疫系の再構築"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"マウス ドウシュ イケイ サイタイケツ イショク ニヨル メンエキケイ ノ サイコウチク"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"45","bibliographicPageStart":"35","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ability of murine allogeneic umbilical cord blood cells （UCBCs） to reconstitute the immune system\nwas investigated. UCBCs obtained from fetuses of C57BL/6 （B6; H-2b） mice, which were transgenic for green\nfluorescent protein （GFP）, were transplanted into RAG2 （-/-） BALB/c mice （H-2d）. After transplantation, flow\ncytometric analysis revealed successful reconstitution of phenotypically mature GFP-positive immune cells of donor\norigin, including T cells, B cells, monocytes, and granulocytes in the peripheral blood of the recipient mice. Analysis\nof functional maturation of lymphocytes revealed that 2,4,6-trinitrophenyl-keyhole limpet hemocyanin （TNP-KLH）\n-immunized UCBC-transplanted recipients produced both TNP-specific IgM and IgG antibodies. These results\nindicated that the recipient mice were capable of mounting antibody responses to T-dependent antigens; further, Ig\nclass switching from IgM to IgG confi rmed that both B cells and CD4+ helper T cells derived from allogeneic UCBCs\nwere immunologically competent. Furthermore, mice transplanted with allogeneic UCBCs accepted skin grafts from\nboth B6 and BALB/c mice. However, these chimeric mice completely rejected skin grafts from third party C3H/\nHeJ （H-2k） mice, indicating the presence of functional CD8+ killer T cells as well as CD4+ helper T cells. In terms\nof potential clinical application, our results indicate that allogeneic UCBC transplantation can enable recovery of the\nnormal immune system in recipients.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(1), 2010, p.35-45","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12200","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ヒデアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12201","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, マサシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12202","nameIdentifierScheme":"WEKO"}],"names":[{"name":"チバ, マキエ"}]},{"nameIdentifiers":[{"nameIdentifier":"12203","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, キョウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12204","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, コウイチ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12205","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 英明"}]},{"nameIdentifiers":[{"nameIdentifier":"12206","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 雅"}]},{"nameIdentifiers":[{"nameIdentifier":"12207","nameIdentifierScheme":"WEKO"}],"names":[{"name":"千葉, 真希枝"}]},{"nameIdentifiers":[{"nameIdentifier":"12208","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 京子"}]},{"nameIdentifiers":[{"nameIdentifier":"12209","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 巧一"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.1","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"Department of Medical Technology, Hirosaki University School of Health Sciences"},{"subitem_text_value":"Department of Medical Technology, Hirosaki University School of Health Sciences"},{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sato, Hideaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Masashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Chiba, Makie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Koichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61(1)_35.pdf","filesize":[{"value":"618.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61(1)_35.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3670/files/HirosakiMedJ_61(1)_35.pdf"},"version_id":"b404726e-db3b-4b39-be45-9d0c61ad3a86"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"umbilical cord blood","subitem_subject_scheme":"Other"},{"subitem_subject":"reconstitution of immune system","subitem_subject_scheme":"Other"},{"subitem_subject":"allogeneic UCBC transplantation","subitem_subject_scheme":"Other"},{"subitem_subject":"臍帯血","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫系再構築","subitem_subject_scheme":"Other"},{"subitem_subject":"不適合臍帯血移植","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation"}]},"item_type_id":"3","owner":"3","path":["645"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-29"},"publish_date":"2010-03-29","publish_status":"0","recid":"3670","relation_version_is_last":true,"title":["Reconstitution of the Immune System after Murine Allogeneic Umbilical Cord Blood Transplantation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:27:34.006376+00:00"}