@article{oai:hirosaki.repo.nii.ac.jp:00003671,
 author = {Ito, Kyoko and Masuko, Kazutaka and Ito, Koichi},
 issue = {1},
 journal = {弘前医学},
 month = {Mar},
 note = {Contact between dendritic cells（ DCs） and resting T cells is essential for initiation of the primary immune
response. In this study, we examined whether neuronal leucine-rich repeat protein 3 （NLRR3）, a receptor involved
in nerve system development, participates in DC-T cell binding and T-cell activation. We confirmed that NLRR3
is expressed on naive T cells. NLRR3 contains an Arg-Gly-Asp （RGD） motif in its amino acid sequence, for which
several integrins can be considered as potential ligands. Indeed, monocyte-derived DCs expressed several integrins
that can bind to the RGD motif. Functionally, DC-induced resting allogeneic T-cell proliferation was partially inhibited
by addition of integrin-specific antibodies and synthetic RGD peptides, indicating that RGD-containing molecules,
including NLRR3 and several integrins, at least participate in the events of the initial primary immune response
involving naive T cells and DCs. Furthermore, DCs were shown to bind directly to NLRR3-transfected Chinese
hamster ovary cells in a NLRR3-dependent manner, and the binding was removed in the presence of integrin-specifi c
antibodies. These data suggest that NLRR3 plays an important role in initiation of the primary immune response., 弘前医学. 61(1), 2010, p.46-57},
 pages = {46--57},
 title = {Possible Function of Neuronal Leucine-Rich Repeat Protein 3（ NLRR3） in Primary Immune Response},
 volume = {61},
 year = {2010}
}