{"created":"2023-05-15T09:02:47.855870+00:00","id":3671,"links":{},"metadata":{"_buckets":{"deposit":"fe175d69-3930-4a77-9783-71532a6f66ad"},"_deposit":{"created_by":3,"id":"3671","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3671"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003671","sets":["557:561:645"]},"author_link":["12209","12199","12208","12204","12216","12203","12198","12211","12213"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"一次免疫応答におけるNeuronal leucine-rich repeat protein 3(NLRR3)の機能的役割"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"イチジ メンエキ オウトウ ニオケル Neuronal leucine-rich repeat protein 3 （NLRR3） ノ キノウテキ ヤクワリ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"46","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Contact between dendritic cells（ DCs） and resting T cells is essential for initiation of the primary immune\nresponse. In this study, we examined whether neuronal leucine-rich repeat protein 3 （NLRR3）, a receptor involved\nin nerve system development, participates in DC-T cell binding and T-cell activation. We confirmed that NLRR3\nis expressed on naive T cells. NLRR3 contains an Arg-Gly-Asp （RGD） motif in its amino acid sequence, for which\nseveral integrins can be considered as potential ligands. Indeed, monocyte-derived DCs expressed several integrins\nthat can bind to the RGD motif. Functionally, DC-induced resting allogeneic T-cell proliferation was partially inhibited\nby addition of integrin-specific antibodies and synthetic RGD peptides, indicating that RGD-containing molecules,\nincluding NLRR3 and several integrins, at least participate in the events of the initial primary immune response\ninvolving naive T cells and DCs. Furthermore, DCs were shown to bind directly to NLRR3-transfected Chinese\nhamster ovary cells in a NLRR3-dependent manner, and the binding was removed in the presence of integrin-specifi c\nantibodies. These data suggest that NLRR3 plays an important role in initiation of the primary immune response.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(1), 2010, p.46-57","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12203","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, キョウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12213","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マスコ, カズタカ"}]},{"nameIdentifiers":[{"nameIdentifier":"12204","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, コウイチ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12208","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 京子"}]},{"nameIdentifiers":[{"nameIdentifier":"12216","nameIdentifierScheme":"WEKO"}],"names":[{"name":"増子, 和尚"}]},{"nameIdentifiers":[{"nameIdentifier":"12209","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 巧一"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"Department of Medical Technology, Hirosaki University School of Health Sciences"},{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ito, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Masuko, Kazutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Koichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61(1)_46.pdf","filesize":[{"value":"482.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61(1)_46.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3671/files/HirosakiMedJ_61(1)_46.pdf"},"version_id":"dcad4c8d-5f8d-46fb-b7fb-edb408cc26a0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"neuronal leucine-rich repeat protein","subitem_subject_scheme":"Other"},{"subitem_subject":"integrin","subitem_subject_scheme":"Other"},{"subitem_subject":"RGD motif","subitem_subject_scheme":"Other"},{"subitem_subject":"dendritic cells","subitem_subject_scheme":"Other"},{"subitem_subject":"adhesion molecule","subitem_subject_scheme":"Other"},{"subitem_subject":"神経関連ロイシンリッチリピートタンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"RGD モチーフ","subitem_subject_scheme":"Other"},{"subitem_subject":"樹状細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"接着分子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Possible Function of Neuronal Leucine-Rich Repeat Protein 3（ NLRR3） in Primary Immune Response","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Possible Function of Neuronal Leucine-Rich Repeat Protein 3（ NLRR3） in Primary Immune Response"}]},"item_type_id":"3","owner":"3","path":["645"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-03-29"},"publish_date":"2010-03-29","publish_status":"0","recid":"3671","relation_version_is_last":true,"title":["Possible Function of Neuronal Leucine-Rich Repeat Protein 3（ NLRR3） in Primary Immune Response"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:27:35.333182+00:00"}