@article{oai:hirosaki.repo.nii.ac.jp:00003672,
 author = {Yokoyama, Hiroaki and Saito, Shin and Higuma, Takumi and Hanada, Hiroyuki and Osanai, Tomohiro and Daitoku, Kazuyuki and Fukuda, Ikuo and Okumura, Ken},
 issue = {1},
 journal = {弘前医学},
 month = {Mar},
 note = {Adipose tissue secretes various bioactive molecules （adipokines）, and apelin is one kind of adipokines.Recently, it was shown that plasma apelin level is decreased in patients with chronic heart failure, and apelin mightplay an important role in the pathogenesis of cardiovascular disease. However, plasma apelin level in coronary arterydisease（ CAD） or other heart disease such as valvular heart disease（ VHD） has not been elucidated. We enrolled 31patients with CAD and 14 patients with VHD who underwent elective cardiac surgery. We also examined plasmaapelin level in 20 healthy subjects （Control）. Blood samples were obtained before the surgery. Paired samples ofvisceral and subcutaneous adipose tissues were harvested during surgery. Plasma apelin level was lower in both CADand VHD than in Control. When compared between CAD and VHD, it was lower in CAD than in VHD, and was notaff ected by treatment with HMG-CoA reductase inhibitors （statins） which was shown to increase adiponectin level.Left ventricular ejection fraction（ LVEF） was lower in CAD than in VHD. There was no correlation between plasmaapelin level and LVEF. Gene expression of apelin in visceral adipose tissue was higher than that in subcutaneousadipose tissue, but it was similar between two groups. These suggest that plasma apelin level was decreased inpatients with cardiac diseases, especially in those with CAD. Its role in the pathophysiology of CAD remains to beelucidated., 弘前医学. 61(1), 2010, p.58-64},
 pages = {58--64},
 title = {Plasma Apelin Level Is Decreased in Patients with Coronary Artery Disease},
 volume = {61},
 year = {2010}
}