{"created":"2023-05-15T09:02:48.283576+00:00","id":3680,"links":{},"metadata":{"_buckets":{"deposit":"2ca28eeb-08fd-4d1d-b789-0ac4f1079040"},"_deposit":{"created_by":3,"id":"3680","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3680"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003680","sets":["557:561:646"]},"author_link":["12191","12178","12193","12184","12181","12192","12179","12189","11307","12185","12187","11312","12370","12190","12363","12180","11302","12182","12186","12356","12183"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Cre/loxP システムを利用したアデノウィルス二重感染法による自殺遺伝子誘導"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"Cre/loxP システム オ リヨウ シタ アデノウィルス ニジュウ カンセンホウ ニヨル ジサツ イデンシ ユウドウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-01-17","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"158","bibliographicPageStart":"150","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We examined the therapeutic efficacy for the suicide gene introduction using two recombinant adenovirus\nvectors with HER2 promoter and Cre/loxP system in human gastric cancer cell lines, MKN-7 and MKN-28. HER2\nprotein level was more expressed in MKN-7 than in MKN-28. Next, we constructed a Cre recombinae expression\nvector in HER2-producing cell specifically, AxHER2NCre and AxCALNCD expressing cytosine deaminase （CD）\ngene under the control of the CAG promoter by the Cre switching system. Much higher CD messenger RNA （CDmRNA） and CD protein expression were induced in cells by the double infection method than by AxCALNCD only.\nFurthermore, CD mRNA and CD protein expression were induced higher in HER2-overexpressing cell line, MKN-\n7 than in MKN-28. We examined the efficacy of cell growth inhibition using 5-fluorocytosine （5-FC） as anti-tumor\nprodrug. Inhibition effect was dose-dependent at each cell line and rate was more in MKN-7 in comparison with\nMKN-28. This system can be applied for HER2-overexpressing cancer specific gene therapy.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(2-4), 2011, p.150-158","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12186","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マルヤマ, マサテル"}]},{"nameIdentifiers":[{"nameIdentifier":"12184","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オダギリ, ヒロキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12185","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イケナガ, ショウジロウカズノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"12183","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ノダガシラ, タツヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"12187","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, トシユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11312","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハカマダ, ケンイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"12363","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ムナカタ, ヒロフミ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12192","nameIdentifierScheme":"WEKO"}],"names":[{"name":"丸山, 将輝"}]},{"nameIdentifiers":[{"nameIdentifier":"12190","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小田桐, 弘毅"}]},{"nameIdentifiers":[{"nameIdentifier":"12191","nameIdentifierScheme":"WEKO"}],"names":[{"name":"池永, 照史郎一期"}]},{"nameIdentifiers":[{"nameIdentifier":"12189","nameIdentifierScheme":"WEKO"}],"names":[{"name":"野田頭, 達也"}]},{"nameIdentifiers":[{"nameIdentifier":"12193","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 利行"}]},{"nameIdentifiers":[{"nameIdentifier":"11307","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"257","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/257_ja.html"}],"names":[{"name":"袴田, 健一"}]},{"nameIdentifiers":[{"nameIdentifier":"12370","nameIdentifierScheme":"WEKO"}],"names":[{"name":"棟方, 博文"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.69","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pediatric Surgery, Hirosaki University"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Maruyama, Masateru"}],"nameIdentifiers":[{"nameIdentifier":"12181","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Odagiri, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"12179","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikenaga, Shojiro-Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"12180","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nodagashira, Tatsuya"}],"nameIdentifiers":[{"nameIdentifier":"12178","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sato, Toshiyuki"}],"nameIdentifiers":[{"nameIdentifier":"12182","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hakamada, Kenichi"}],"nameIdentifiers":[{"nameIdentifier":"11302","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"257","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/257_ja.html"}]},{"creatorNames":[{"creatorName":"Munakata, Hirofumi"}],"nameIdentifiers":[{"nameIdentifier":"12356","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61(2-4)_150.pdf","filesize":[{"value":"312.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61(2-4)_150.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3680/files/HirosakiMedJ_61(2-4)_150.pdf"},"version_id":"81d705cf-5693-4051-9759-d08133c6ec6e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HER2 promoter","subitem_subject_scheme":"Other"},{"subitem_subject":"Cre/loxP system","subitem_subject_scheme":"Other"},{"subitem_subject":"suicide gene","subitem_subject_scheme":"Other"},{"subitem_subject":"CD/5-FC","subitem_subject_scheme":"Other"},{"subitem_subject":"HER2 プロモーター","subitem_subject_scheme":"Other"},{"subitem_subject":"Cre/loxPシステム","subitem_subject_scheme":"Other"},{"subitem_subject":"自殺遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"シトシンデアミナーゼ","subitem_subject_scheme":"Other"},{"subitem_subject":"5－フルオロシトシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"THE SUICIDE GENE INTRODUCTION USING TWO RECOMBINANT ADENOVIRUS VECTORS WITH HER2 PROMOTER AND Cre/loxP SYSTEM","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"THE SUICIDE GENE INTRODUCTION USING TWO RECOMBINANT ADENOVIRUS VECTORS WITH HER2 PROMOTER AND Cre/loxP SYSTEM"}]},"item_type_id":"3","owner":"3","path":["646"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-01-25"},"publish_date":"2011-01-25","publish_status":"0","recid":"3680","relation_version_is_last":true,"title":["THE SUICIDE GENE INTRODUCTION USING TWO RECOMBINANT ADENOVIRUS VECTORS WITH HER2 PROMOTER AND Cre/loxP SYSTEM"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:43:12.977796+00:00"}