{"created":"2023-05-15T09:02:48.409943+00:00","id":3683,"links":{},"metadata":{"_buckets":{"deposit":"409c6c13-5fd8-444a-9974-b8074acb6156"},"_deposit":{"created_by":3,"id":"3683","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3683"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003683","sets":["557:561:647"]},"author_link":["12381","12382","12383","12385","12384"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S10","bibliographicPageStart":"S1","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Leptin is well known to be involved in the inhibition of feeding, thermogenesis, reproduction and neuroendocrine functions through its actions on the rodent hypothalamic receptors. Leptin facilitated the presynaptic transmitter release and postsynaptic sensitivity to the transmitters in the hippocampal CA1 neurons. Thus longterm potentiation （LTP） and the phosphorylation of Ca2+/calmodulin protein kinase II （CaMK II） were facilitated in the CA1 neurons. Therefore behavioral performance related to spatial learning and memory was improved by leptin in vivo applications. Orexin-A produced by glucose-sensitive neurons in the lateral hypothalamic area （LHA）and released during food intake facilitates feeding. Orexin-A suppressed LTP and CaMK II phosphorylation without affecting the presynaptic transmitter release. Therefore behavioral performance on learning and memory was impaired. The present studies suggest that leptin and orexin signalings in the brain may have important implications for cognitive function.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S1-S10","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University"},{"subitem_text_value":"Department of Brain Science and Engineering, Graduate School of Life Science and Systems Engineering, Kitakyushu Institute of Technology"},{"subitem_text_value":"Department of Pharmacology, Faculty of Pharmacy, Tohoku University"},{"subitem_text_value":"Department of Pharmacology, Faculty of Pharmacy, Tohoku University"},{"subitem_text_value":"Division of Bio-Information Engineering, Faculty of Engineering, University of"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oomura, Yutaka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aou, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukunaga, Kouji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Moriguchi, Sigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sasaki, Kazuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S1.pdf","filesize":[{"value":"409.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S1.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3683/files/HirosakiMedJ_61_S1.pdf"},"version_id":"bc0dc386-ec5b-4524-837c-fd3c602fdb88"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Leptin","subitem_subject_scheme":"Other"},{"subitem_subject":"Orexin","subitem_subject_scheme":"Other"},{"subitem_subject":"CaMK II phosphorylation","subitem_subject_scheme":"Other"},{"subitem_subject":"Facilitation and impairment of learning and memory in rodents","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-02"},"publish_date":"2010-08-02","publish_status":"0","recid":"3683","relation_version_is_last":true,"title":["＜Symposium I＞Prandial increases of leptin and orexin in the brain modulate spatial learning and memory"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T12:33:12.707816+00:00"}