@article{oai:hirosaki.repo.nii.ac.jp:00003687,
 author = {Kato, Yukio and Noshiro, Mitsuhide and Fujimoto, Katsumi and Kawamoto, Takeshi},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Jul},
 note = {We cloned Dec1 （Differentiated embryonic chondrocyte-1） and a similar gene, Dec2, in 1997 and 2000, respectively. DEC structure is similar to that of HES1 and HAIRY, and we observed circadian rhythms of Dec1 mRNA levels in chondrocytes in vitro and rat liver in vivo. We then attempted to fi nd out whether these genes are implicated in the circadian pacemaker: We found that a mutation of Clock abolishes or shifts circadian expression of Dec1 and/or Dec2 in most tissues, including the suprachiasmatic nucleus（ SCN）, and that DEC1 and DEC2 modulate their own circadian expression and that of some other clock genes by auto-regulatory and interlocked feedback mechanisms. Studies on defi ciencies of these genes indicate that Dec1 and Dec2 play roles in the phase shift and maintenance of accurate circadian rhythms and clock outputs to some physiological activities. We speculate that clock genes, including Dec, are involved in the pathology of various diseases and aging., 弘前医学. 61(Suppl.), 2010, p.S34-S42},
 pages = {S34--S42},
 title = {＜Symposium I＞Roles of DEC1 and DEC2 in the core loop of the circadian clock, and clock outputs to metabolism},
 volume = {61},
 year = {2010}
}