{"created":"2023-05-15T09:02:48.881686+00:00","id":3692,"links":{},"metadata":{"_buckets":{"deposit":"fbf96f82-dbc5-4e81-a35b-edb620453554"},"_deposit":{"created_by":3,"id":"3692","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3692"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003692","sets":["557:561:647"]},"author_link":["12444","9403","12446","11869","12451","9404","9399","9396","9397","12450","9400","12447"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S88","bibliographicPageStart":"S80","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"α-Synucleinopathies comprise a group of neurodegenerative disorders that share α-synuclein （αS）accumulation in selected vulnerable neurons and glia, i.e. Parkinson’s disease （PD）, dementia with Lewy bodies and multiple system atrophy（ MSA）. The histological hallmark of PD is neuronal αS aggregates called Lewy bodies（ LBs）. LB formation has been considered to be a marker for neuronal degeneration, because neuronal loss is found in the predilection sites for LBs. However, recent studies have suggested that oligomers and protofi brils of αS are cytotoxic, and that LBs may represent a cytoprotective mechanism in PD. The histological hallmark of MSA is αS aggregates in the oligodendrocytes referred to as glial cytoplasmic inclusions（ GCIs）. αS inclusions are also found in the neuronal somata, axons and nucleus. At present, two degenerative processes have been considered in this disease; one is due to the widespread occurrence of GCIs associated with oligodendroglia-myelin degeneration, and the other is due to the aggregation of αS in neurons in several brain regions. These two processes might synergistically cause neuronal depletion in MSA.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S80-S88","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9399","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ワカバヤシ, コウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"12446","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミキ, ヤスオ"}]},{"nameIdentifiers":[{"nameIdentifier":"12447","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タンジ, クニカズ"}]},{"nameIdentifiers":[{"nameIdentifier":"9400","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリ, フミアキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"9396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"312","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/312_ja.html"}],"names":[{"name":"若林, 孝一"}]},{"nameIdentifiers":[{"nameIdentifier":"12450","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000703","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000703_ja.html"}],"names":[{"name":"三木, 康生"}]},{"nameIdentifiers":[{"nameIdentifier":"12451","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"314","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/314_ja.html"}],"names":[{"name":"丹治, 邦和"}]},{"nameIdentifiers":[{"nameIdentifier":"9397","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"313","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/313_ja.html"}],"names":[{"name":"森, 文秋"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuropathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuropathology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Wakabayashi, Koichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miki, Yasuo"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Mori, Fumiaki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S80.pdf","filesize":[{"value":"343.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S80.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3692/files/HirosakiMedJ_61_S80.pdf"},"version_id":"44bef838-e9da-4569-932e-23c280c19533"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Parkinson’s disease","subitem_subject_scheme":"Other"},{"subitem_subject":"Lewy body","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple system atrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"glial cytoplasmic inclusion","subitem_subject_scheme":"Other"},{"subitem_subject":"α-synuclein","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Symposium III＞Pathology of neuro-glial α-synucleinopathy (Lewy body disease and multiple system atrophy)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Symposium III＞Pathology of neuro-glial α-synucleinopathy (Lewy body disease and multiple system atrophy)"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-16"},"publish_date":"2010-08-16","publish_status":"0","recid":"3692","relation_version_is_last":true,"title":["＜Symposium III＞Pathology of neuro-glial α-synucleinopathy (Lewy body disease and multiple system atrophy)"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T11:20:00.218617+00:00"}