{"created":"2023-05-15T09:02:49.056246+00:00","id":3695,"links":{},"metadata":{"_buckets":{"deposit":"07a2eff9-813e-4575-9b30-e7b1523df43e"},"_deposit":{"created_by":3,"id":"3695","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3695"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003695","sets":["557:561:647"]},"author_link":["12471","12468","12474","12481","12467","12469","12473","12465","12470","12480","12476","12460","12463","12472","12478","12461","12466","12477","12464","12479","12475","12462"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S110","bibliographicPageStart":"S105","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Alzheimer's disease (AD) is the major and common disease usually for aged people to show progressive neurodegenerative disorder with the dementia. Amyloid-beta （also β-protein and referred here to as Aβ） is a wellestablished seminal peptide in AD that is produced from the amyloid precursor protein （APP） by consecutive digestions with β-secretase of BACE and gamma-secretase of the presenilin complex. Abnormal cerebral accumulation of Aβ such as insoluble fi brils in senile plaques and cerebral amyloid angiopathy （CAA） are observed as a neuropathological hallmark of AD. In contrast to such insoluble fi brillary Aβ, a soluble oligomeric complex is discussed as ADDLs, Aβ oligomer, low-n oligomer Aβ, Aβ*56 or so. Despite their diff erent names, it is proposed as the current hypothesis that oligomeric Aβ is the direct molecule to cause synaptic toxicity and cognitive dysfunction in the early stages of AD. We identifi ed a novel APP mutation （E693delta; referred to as the Osaka mutation） in a pedigree with probable AD resulting in a variant Aβ lacking glutamate at position 22. Based on theoretical prediction and in vitro studies on synthetic mutant Aβ peptides, the mutated Aβ peptide showed a unique aggregation property of enhanced oligomerization but no fi brillization. This was further confi rmed by PiB-PET analysis on the proband patient. Collectively together, we conclude that the Osaka mutation is the fi rst human evidence for the hypothesis that oligomeric Aβ is involved in AD.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S105-S110","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Neuroscience and Neurology,Osaka City University Medical School"},{"subitem_text_value":"Department of Pharmaceutical Sciences, Himeji Dokkyo University"},{"subitem_text_value":"Department of Behavior Science, Hyogo University of Health Sciences"},{"subitem_text_value":"Department of Physiology, Hyogo College of Medicine"},{"subitem_text_value":"Department of Physiology, Hyogo College of Medicine"},{"subitem_text_value":"Department of Physiology, Osaka City University Medical School"},{"subitem_text_value":"Department of Physiology, Osaka City University Medical School"},{"subitem_text_value":"Department of Physiology, Osaka City University Medical School"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Mori, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomiyama, Takami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Kennichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohnishi, Kiyouhisa"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Teraoka, Rie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukushima, Akiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takuma, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shimada, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ataka, Suzuka"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Umeda, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kitajima, Erika"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fujita, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamashita, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Keiichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Miki, Takami"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Matsuyama, Shogo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Iso, Hiroyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nagata, Tetsu"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishizaki, Tomoyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wada, Yasuhiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yoshioka, Eito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Watanabe, Yasuyoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S105.pdf","filesize":[{"value":"199.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S105.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3695/files/HirosakiMedJ_61_S105.pdf"},"version_id":"6c56c20f-57e2-4709-95b9-795a91b60375"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Alzheimer’s disease","subitem_subject_scheme":"Other"},{"subitem_subject":"amyloid genetics","subitem_subject_scheme":"Other"},{"subitem_subject":"oligomeric Aβ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Symposium IV＞Oligomeric Aβ is the sole culprit molecule to cause Alzheimer's disease?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Symposium IV＞Oligomeric Aβ is the sole culprit molecule to cause Alzheimer's disease?"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-18"},"publish_date":"2010-08-18","publish_status":"0","recid":"3695","relation_version_is_last":true,"title":["＜Symposium IV＞Oligomeric Aβ is the sole culprit molecule to cause Alzheimer's disease?"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T12:32:35.972804+00:00"}