{"created":"2023-05-15T09:02:49.265622+00:00","id":3700,"links":{},"metadata":{"_buckets":{"deposit":"5186fe42-93a6-48a7-9a7f-b56d64fa6da3"},"_deposit":{"created_by":3,"id":"3700","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3700"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003700","sets":["557:561:647"]},"author_link":["11463","12438","11447","12520","12528","12523","12519","12440","11869","12439","12513","12514","11451","11458","12447","12451","12436","11449","11452","11871","12435","11459","11456","11898","12512","12521","11448"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S156","bibliographicPageStart":"S147","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Optimization of neuronal function and survival is an important goal in the treatment of cerebrovascular diseases in order to avoid or improve devastating long-term sequelae. Nerve growth factor （NGF） is essential for neuronal growth and survival in the central nervous system （CNS）. Vascular endothelial growth factor （VEGF） is a potent mitogen specifi c for endothelial cells and a stimulator of neovascularization. VEGF also enhances vascular permeability, which may promote the development of brain edema during cerebral ischemia. These molecules aff ect the outcome of ischemia/reperfusion injury in the CNS. Edaravone, a brain-penetrant, free radical scavenger, is known to ameliorate postischemic neuronal dysfunction. Transcription factor Nrf2（ nuclear factor-erythroid 2-related factor 2）, a master regulator of antioxidant responses, plays an important role in the coordinated expressions of stress-inducible genes. Astrocytes express various genes involved in the regulation of neuronal functions, and the regulation of astrocyte gene expressions may be a potential therapeutic target in brain injury. This review aims to appraise the eff ects of radical scavenger edaravone and a natural Nrf2-inducer as neuroprotective agents in human astrocytes, particularly under an experimental model for hypoxia/reoxygenation.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S147-S156","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11452","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, ヒデミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12439","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミムラ, ジュンセイ"}]},{"nameIdentifiers":[{"nameIdentifier":"11451","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イマイズミ, タダアツ"}]},{"nameIdentifiers":[{"nameIdentifier":"12519","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツミヤ, トモオ"}]},{"nameIdentifiers":[{"nameIdentifier":"12520","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシカワ, アキラ"}]},{"nameIdentifiers":[{"nameIdentifier":"12521","nameIdentifierScheme":"WEKO"}],"names":[{"name":"メトキ, ノリフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12447","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タンジ, クニカズ"}]},{"nameIdentifiers":[{"nameIdentifier":"12523","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオタ, ケン"}]},{"nameIdentifiers":[{"nameIdentifier":"12438","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, ケン"}]},{"nameIdentifiers":[{"nameIdentifier":"11456","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ケイ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 秀見"}]},{"nameIdentifiers":[{"nameIdentifier":"11447","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"318","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/318_ja.html"}],"names":[{"name":"今泉, 忠淳"}]},{"nameIdentifiers":[{"nameIdentifier":"12528","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石川, 玲"}]},{"nameIdentifiers":[{"nameIdentifier":"12451","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"314","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/314_ja.html"}],"names":[{"name":"丹治, 邦和"}]},{"nameIdentifiers":[{"nameIdentifier":"12440","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊東, 健"}]},{"nameIdentifiers":[{"nameIdentifier":"11449","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 敬"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Stress Response Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Disability and Health, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"Department of Internal Medicine, Hirosaki Stroke Center"},{"subitem_text_value":"Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Research and Development Center, Nagase & Co. Ltd."},{"subitem_text_value":"Department of Stress Response Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mimura, Junsei"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Imaizumi, Tadaatsu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Matsumiya, Tomoh"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishikawa, Akira"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Metoki, Norifumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ota, Ken"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kosaka, Kunio"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Ken"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Satoh, Kei"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S147.pdf","filesize":[{"value":"146.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S147.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3700/files/HirosakiMedJ_61_S147.pdf"},"version_id":"f300d44a-9f32-4049-b7c5-2071a77ad573"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Edaravone","subitem_subject_scheme":"Other"},{"subitem_subject":"Nrf2","subitem_subject_scheme":"Other"},{"subitem_subject":"Carnosic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"NGF","subitem_subject_scheme":"Other"},{"subitem_subject":"Reperfusion","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-18"},"publish_date":"2010-08-18","publish_status":"0","recid":"3700","relation_version_is_last":true,"title":["＜Symposium V＞Edaravone and Nrf2-inducers as neuroprotective agents in human astrocytes exposed to hypoxia/reoxygenation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:27:12.038668+00:00"}