{"created":"2023-05-15T09:02:49.350939+00:00","id":3702,"links":{},"metadata":{"_buckets":{"deposit":"1bdab9b5-043e-4fe7-81f7-72d1477edf29"},"_deposit":{"created_by":3,"id":"3702","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3702"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003702","sets":["557:561:647"]},"author_link":["12534"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S173","bibliographicPageStart":"S164","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Prostaglandin（ PG） D2 is the most potent endogenous sleep-promoting substance thus far reported and its sleep-inducing mechanism is the best characterized at the molecular level. PGD2 is produced by lipocalin-type PGD synthase （L-PGDS） localized in the leptomeninges, choroid plexus, and oligodendrocytes in the brain and is secreted into the cerebrospinal fluid as a sleep hormone. PGD2 stimulates DP1 receptors localized in the arachnoid membrane at the basal forebrain to release adenosine as a paracrine sleep-promoting molecule, which activates adenosine A2A receptor-expressing neurons located in the basal forebrain. These cells subsequently excite the sleep-active neurons in the ventrolateral preoptic area and concomitantly suppress the tuberomammillary nucleus, a histaminergic arousal center, through GABAergic and galaninergic inhibitory projection, to induce sleep. The administration of a PGD synthase inhibitor （SeCl4）, DP1 antagonist （ONO-4127Na） or adenosine A2 receptor antagonist （caffeine） induces insomnia, indicating that the PGD2-adenosine system is crucial for the maintenance of physiological sleep.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S164-S173","subitem_description_type":"Other"}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Molecular Behavioral Biology, Osaka Bioscience Institute"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Urade, Yoshihiro"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S164.pdf","filesize":[{"value":"330.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S164.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3702/files/HirosakiMedJ_61_S164.pdf"},"version_id":"30229f07-b5a5-4078-bc7c-09957abd22de"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"prostaglandin D_2","subitem_subject_scheme":"Other"},{"subitem_subject":"adenosine","subitem_subject_scheme":"Other"},{"subitem_subject":"ventrolateral preoptic area","subitem_subject_scheme":"Other"},{"subitem_subject":"tuberomammillary nucleus","subitem_subject_scheme":"Other"},{"subitem_subject":"histamine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Special Seminar＞Molecular mechanism of sleep-wake regulation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Special Seminar＞Molecular mechanism of sleep-wake regulation"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-18"},"publish_date":"2010-08-18","publish_status":"0","recid":"3702","relation_version_is_last":true,"title":["＜Special Seminar＞Molecular mechanism of sleep-wake regulation"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T12:32:31.742630+00:00"}