{"created":"2023-05-15T09:02:49.601869+00:00","id":3708,"links":{},"metadata":{"_buckets":{"deposit":"78f8b472-a14e-49d2-9fce-f4f7cc5c3bdc"},"_deposit":{"created_by":3,"id":"3708","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3708"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003708","sets":["557:561:647"]},"author_link":["9403","12570","11869","11459","11452","12451","9404","9399","12562","11448","9397","9396","9400","12561","12447","12565"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S210","bibliographicPageStart":"S204","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"TDP-43 proteinopathy （amyotrophic lateral sclerosis and frontotemporal lobar degeneration with ubiquitin-positive inclusions） is a newly categorized group of neurodegenerative disorders characterized by abnormal accumulation and mislocalization of nuclear TDP-43 protein in the neuronal cytoplasm. 15-deoxy-Δ12,14-prostaglandin J2 （15d-PGJ2） is non-enzymatically produced from PGD2, and plays roles in infl ammation and oxidative stress responses. Indeed, 15d-PGJ2 is up-regulated in the spinal motor neurons in ALS. In this study, biochemical and fluorescent staining analyses showed that 15d-PGJ2 modifi es expression, solubility, and subcellular localization of TDP-43. This alteration was at least partly related to a cyclopentenone ring structure containing an electrophilic carbon of 15d-PGJ2, because 15d-PGJ2 analogue, which lacks an cyclopentenone ring structure, had almost no eff ect on TDP-43 protein. Finally in vitro binding experiment indicated that 15d-PGJ2 is covalently bound to TDP-43 protein. These fi ndings suggest that a sustained high level of 15d-PGJ2 is involved in the pathogenesis of neurodegenerative disorders related to abnormal TDP-43 protein.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S204-S210","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12447","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タンジ, クニカズ"}]},{"nameIdentifiers":[{"nameIdentifier":"11452","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヨシダ, ヒデミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12565","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤカリ, マコト"}]},{"nameIdentifiers":[{"nameIdentifier":"9400","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリ, フミアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"9399","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ワカバヤシ, コウイチ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12451","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"314","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/314_ja.html"}],"names":[{"name":"丹治, 邦和"}]},{"nameIdentifiers":[{"nameIdentifier":"11448","nameIdentifierScheme":"WEKO"}],"names":[{"name":"吉田, 秀見"}]},{"nameIdentifiers":[{"nameIdentifier":"12570","nameIdentifierScheme":"WEKO"}],"names":[{"name":"早狩, 誠"}]},{"nameIdentifiers":[{"nameIdentifier":"9397","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"313","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/313_ja.html"}],"names":[{"name":"森, 文秋"}]},{"nameIdentifiers":[{"nameIdentifier":"9396","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"312","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/312_ja.html"}],"names":[{"name":"若林, 孝一"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pharmaceutical Science, Hirosaki University Hospital"},{"subitem_text_value":"Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Departments of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Zhang, Hai-xin"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tanji, Kunikazu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yoshida, Hidemi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakari, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mori, Fumiaki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wakabayashi, Koichi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S204.pdf","filesize":[{"value":"448.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S204.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3708/files/HirosakiMedJ_61_S204.pdf"},"version_id":"21926e4b-9258-4f32-9500-fc435e0f758b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Amyotrophic lateral sclerosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Frontotemporal lobar degeneration","subitem_subject_scheme":"Other"},{"subitem_subject":"15d-PGJ2","subitem_subject_scheme":"Other"},{"subitem_subject":"Prostaglandin","subitem_subject_scheme":"Other"},{"subitem_subject":"TDP-43 proteinopathy","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal 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proteinopathy"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T11:20:40.021760+00:00"}