@article{oai:hirosaki.repo.nii.ac.jp:00003711,
 author = {Sashinami, Hiroshi and Hu, Dong-Liang and Li, Sheng-Jun and Mitsui, Toshihito and Hakamada, Kenichi and Ishiguro, Yoh and Fukuda, Shinsaku and Nakane, Akio},
 issue = {Supplement},
 journal = {弘前医学},
 month = {Jul},
 note = {We investigated the eff ect of p60 that is one of virulence factors of Listeria monocytogenes on host immune response in vitro and in vivo. C57BL/6 mice immunized with p60 showed antigen-specifi c T-helper I type immune response. Mouse macrophage RAW264.7 cells produced tumor necrosis factor alpha （TNF-α）, interleukin-12 and interferon beta （IFN-β） in response to stimulation with recombinant p60. Administration of p60 prior to a sublethal infection with L. monocytogenes enhanced innate host resistance in naïve mice. TNF-α and IFN-β production from RAW264.7 cells and bone marrow-derived macrophages were Toll-like receptor 4 （TLR4）-dependent. The enhanced clearance of L. monocytogenes by p60 administration was not shown in C3H/HeJ mice. Our fi ndings demonstrated that p60 enhances host resistance against L. monocytngenes infection through both activation and attenuation of host innate immune response in the TLR4-dependent manner., 弘前医学. 61(Suppl.), 2010, p.S224-S231},
 pages = {S224--S231},
 title = {＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews},
 volume = {61},
 year = {2010}
}