{"created":"2023-05-15T09:02:49.727055+00:00","id":3711,"links":{},"metadata":{"_buckets":{"deposit":"252661cc-2e8a-42f7-8580-65f6071288ab"},"_deposit":{"created_by":3,"id":"3711","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3711"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003711","sets":["557:561:647"]},"author_link":["12603","11678","12596","11495","11686","12592","11502","11191","11493","11307","11696","11512","11181","11492","12604","11312","11172","11506","12593","11483","11487","11302","11501"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S231","bibliographicPageStart":"S224","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"We investigated the eff ect of p60 that is one of virulence factors of Listeria monocytogenes on host immune response in vitro and in vivo. C57BL/6 mice immunized with p60 showed antigen-specifi c T-helper I type immune response. Mouse macrophage RAW264.7 cells produced tumor necrosis factor alpha （TNF-α）, interleukin-12 and interferon beta （IFN-β） in response to stimulation with recombinant p60. Administration of p60 prior to a sublethal infection with L. monocytogenes enhanced innate host resistance in naïve mice. TNF-α and IFN-β production from RAW264.7 cells and bone marrow-derived macrophages were Toll-like receptor 4 （TLR4）-dependent. The enhanced clearance of L. monocytogenes by p60 administration was not shown in C3H/HeJ mice. Our fi ndings demonstrated that p60 enhances host resistance against L. monocytngenes infection through both activation and attenuation of host innate immune response in the TLR4-dependent manner.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S224-S231","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11495","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サシナミ, ヒロシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11493","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フウ, ドンリャン"}]},{"nameIdentifiers":[{"nameIdentifier":"12596","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミツイ, トシヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"11312","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハカマダ, ケンイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"11686","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシグロ, ヨウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11181","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フクダ, シンサク"}]},{"nameIdentifiers":[{"nameIdentifier":"11501","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカネ, アキオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11487","nameIdentifierScheme":"WEKO"}],"names":[{"name":"差波, 拓志"}]},{"nameIdentifiers":[{"nameIdentifier":"11483","nameIdentifierScheme":"WEKO"}],"names":[{"name":"胡, 東良"}]},{"nameIdentifiers":[{"nameIdentifier":"12603","nameIdentifierScheme":"WEKO"}],"names":[{"name":"李, 勝軍"}]},{"nameIdentifiers":[{"nameIdentifier":"12604","nameIdentifierScheme":"WEKO"}],"names":[{"name":"三ツ井, 敏仁"}]},{"nameIdentifiers":[{"nameIdentifier":"11307","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"257","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/257_ja.html"}],"names":[{"name":"袴田, 健一"}]},{"nameIdentifiers":[{"nameIdentifier":"11678","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石黒, 陽"}]},{"nameIdentifiers":[{"nameIdentifier":"11172","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"226","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/226_ja.html"}],"names":[{"name":"福田, 眞作"}]},{"nameIdentifiers":[{"nameIdentifier":"11492","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中根, 明夫"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Digestive Surgery, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sashinami, Hiroshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hu, Dong-Liang"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Li, Sheng-Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mitsui, Toshihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hakamada, Kenichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ishiguro, Yoh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Fukuda, Shinsaku"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S224.pdf","filesize":[{"value":"200.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S224.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3711/files/HirosakiMedJ_61_S224.pdf"},"version_id":"2270e890-9c50-46b2-b63a-13fb2e3c031b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Listeria monocytogenes","subitem_subject_scheme":"Other"},{"subitem_subject":"p60","subitem_subject_scheme":"Other"},{"subitem_subject":"TLR4","subitem_subject_scheme":"Other"},{"subitem_subject":"TNF-α","subitem_subject_scheme":"Other"},{"subitem_subject":"IFN-β","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-19"},"publish_date":"2010-08-19","publish_status":"0","recid":"3711","relation_version_is_last":true,"title":["＜Poster＞Immunization with nontoxic mutant staphylococcal enterotoxin a protects against enterotoxin-induced emesis in house musk shrews"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:37:52.103855+00:00"}