{"created":"2023-05-15T09:02:49.811451+00:00","id":3713,"links":{},"metadata":{"_buckets":{"deposit":"a3e32ccb-8182-4306-94d4-b01f5b8c9546"},"_deposit":{"created_by":3,"id":"3713","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3713"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003713","sets":["557:561:647"]},"author_link":["12618","11493","11512","11494","11502","11501"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S244","bibliographicPageStart":"S238","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Clumping factor A （ClfA） is an adhesin of Staphylococcus aureus, and the residues 40-559 of ClfA （ClfA40-559） compose fi brinogen binding domain. It was reported that antibody to ClfA40-559 plays an important role in the protective eff ects. In this study, we investigated the role of IL-17 in the protective eff ects of an immunization with ClfA40-559 against S. aureus infection.\n　Mice immunized or non-immunized with ClfA40-559 were challenged with S. aureus. Bacterial numbers in the organs and survival rates were evaluated. RAW264.7, DC2.4 and spleen cells of naïve and immunized mice were stimulated with ClfA40-559. Cytokine production and mRNA expression in the spleens and cells was determined by ELISA and/or RT-PCR.\n　The survival rate was improved and the bacterial numbers in the organs were reduced in the mice immunized with ClfA40-559. ClfA40-559 induced IL-23p19 mRNA expression and IL-6 but not IL-12 production in DC2.4 and RAW264.7 cells. RORγt and IL-17A mRNA expression in the spleen cells of naïve mice was induced. In the spleen cells of immunized mice, ClfA40-559 induced the high production of IL-17 but not IFN-γ or IL-4. IL-17A, IL-6 and CXCL2 mRNA expression was also increased in the organs of immunized and challenged mice. These results suggest that an immunization with ClfA40-559 induces Th17, and that IL-17 contributes to host defense in early phase of S. aureus infection by promoting neutrophil recruitment.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S238-S244","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11494","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナリタ, コウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11493","nameIdentifierScheme":"WEKO"}],"names":[{"name":"フウ, ドンリャン"}]},{"nameIdentifiers":[{"nameIdentifier":"11501","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカネ, アキオ"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Narita, Koji"}],"nameIdentifiers":[{"nameIdentifier":"12618","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hu, Dong-Liang"}],"nameIdentifiers":[{"nameIdentifier":"11502","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{"nameIdentifier":"11512","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S238.pdf","filesize":[{"value":"160.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S238.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3713/files/HirosakiMedJ_61_S238.pdf"},"version_id":"aea03030-033d-4dd8-89fe-0e752a7a1054"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Staphylococcus aureus","subitem_subject_scheme":"Other"},{"subitem_subject":"Clumping factor A","subitem_subject_scheme":"Other"},{"subitem_subject":"Immunization","subitem_subject_scheme":"Other"},{"subitem_subject":"IL-17","subitem_subject_scheme":"Other"},{"subitem_subject":"Th17","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Poster＞The role of interleukin-17 in the protective effect of an immunization with clumping factor A against Staphylococcus aureus infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Poster＞The role of interleukin-17 in the protective effect of an immunization with clumping factor A against Staphylococcus aureus infection"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-19"},"publish_date":"2010-08-19","publish_status":"0","recid":"3713","relation_version_is_last":true,"title":["＜Poster＞The role of interleukin-17 in the protective effect of an immunization with clumping factor A against Staphylococcus aureus infection"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:29:55.917620+00:00"}