{"created":"2023-05-15T09:02:49.853271+00:00","id":3714,"links":{},"metadata":{"_buckets":{"deposit":"51b53a61-cecb-4716-8c92-fc5fa48b7ef1"},"_deposit":{"created_by":3,"id":"3714","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3714"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003714","sets":["557:561:647"]},"author_link":["12073","12081","12628","12074","11203","12633","11213","12076","12077","12082","12071","12072","12083","12078","11223","12623"],"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-07-08","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"Supplement","bibliographicPageEnd":"S251","bibliographicPageStart":"S245","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Iron is essential for a variety of cellular functions. However iron, especially ferrous form, has the potential for catalyzing the Fenton reaction to generate highly cytotoxic hydroxyl radicals. Therefore the amount of iron in the brain is strictly controlled. In this study we focused on the cellular and subcellular localizations of nonheme ferric （Fe（III）） and ferrous （Fe（II）） iron in the adult female rat brain by light and electron microscopic histochemistry. Although Fe（II） deposition was much less dominant than Fe（III）, the brain contained iron in both forms. Among the cellular elements of the brain, oligodendrocytes were numerically most prominent and heavily iron-storing cells. Pericapillary astrocytes and sporadic microglial cells also showed dense iron accumulation. Large neurons involved in the motor system were relatively strongly iron-positive. Subcellularly, Fe（III） and Fe（II） were mainly localized in lysosomes, and occasionally in the cytosol and mitochondria. Fe（II）-specific deposit was shown on the luminal membrane of endothelium. With advancing age, both Fe（III） and Fe（II） became distributed more extensively, and accumulated more numerously into oligodendrocytes.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 61(Suppl.), 2010, p.S245-S251","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12077","nameIdentifierScheme":"WEKO"}],"names":[{"name":"メグロ, レイコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12078","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アサノ, ヨシヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"12076","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オダギリ, サオリ"}]},{"nameIdentifiers":[{"nameIdentifier":"11213","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ショウムラ, カズヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12628","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イチノヘ, ノリタカ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12082","nameIdentifierScheme":"WEKO"}],"names":[{"name":"目黒, 玲子"}]},{"nameIdentifiers":[{"nameIdentifier":"12083","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"183","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/183_ja.html"}],"names":[{"name":"浅野, 義哉"}]},{"nameIdentifiers":[{"nameIdentifier":"12081","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小田桐, 紗織"}]},{"nameIdentifiers":[{"nameIdentifier":"11203","nameIdentifierScheme":"WEKO"}],"names":[{"name":"正村, 和彦"}]},{"nameIdentifiers":[{"nameIdentifier":"12633","nameIdentifierScheme":"WEKO"}],"names":[{"name":"一戸, 紀孝"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neuroanatomy, Cell Biology and Histology, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Meguro, Reiko"}],"nameIdentifiers":[{"nameIdentifier":"12073","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Asano, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"12074","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"183","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/183_ja.html"}]},{"creatorNames":[{"creatorName":"Odagiri, Saori"}],"nameIdentifiers":[{"nameIdentifier":"12072","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Li, Chengtai"}],"nameIdentifiers":[{"nameIdentifier":"12071","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoumura, Kazuhiko"}],"nameIdentifiers":[{"nameIdentifier":"11223","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ichinohe, Noritaka"}],"nameIdentifiers":[{"nameIdentifier":"12623","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_61_S245.pdf","filesize":[{"value":"278.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_61_S245.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3714/files/HirosakiMedJ_61_S245.pdf"},"version_id":"647d76f0-6564-4c3d-abb5-5fb030e32bda"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"nonheme iron","subitem_subject_scheme":"Other"},{"subitem_subject":"perfusion-Perls method","subitem_subject_scheme":"Other"},{"subitem_subject":"perfusion-Turnbull method","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"＜Poster＞Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain : a light and electron microscopic study by the perfusion-Perls and -Turnbull methods","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"＜Poster＞Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain : a light and electron microscopic study by the perfusion-Perls and -Turnbull methods"}]},"item_type_id":"3","owner":"3","path":["647"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-08-19"},"publish_date":"2010-08-19","publish_status":"0","recid":"3714","relation_version_is_last":true,"title":["＜Poster＞Cellular and subcellular localizations of nonheme ferric and ferrous iron in the rat brain : a light and electron microscopic study by the perfusion-Perls and -Turnbull methods"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:03:14.154708+00:00"}