{"created":"2023-05-15T09:02:50.022595+00:00","id":3718,"links":{},"metadata":{"_buckets":{"deposit":"a1702817-75bb-4168-b2ed-50a0d0942722"},"_deposit":{"created_by":3,"id":"3718","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3718"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003718","sets":["557:561:648"]},"author_link":["11662","11672","11463","12683","12673","12672","11163","11447","11671","12668","11153","11147","12682","11451","11863","11458","11161","11449","12667","12674","12669","11531","11456","11517","11664","11155","11524"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Ultraviolet B Irradiation Inhibits Retinoic Acid-Inducible Gene-I Expression in Human Keratinocytes（in Japanese）"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"チュウハチョウ シガイセン UVB ワ ヒト ヒョウヒ サイボウ ノ RETINOIC ACID-INDUCIBLE GENE-I ハツゲン ユウドウ オ ヨクセイ スル"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Retinoic acid-inducible gene-I（RIG-I）はウイルスの二本鎖RNAを認識しtype I interferon（IFN）の産生を誘導する細胞質蛋白である．ヒト表皮細胞ではRIG-IはIFN-γ およびtumor necrosis factor-α刺激によって誘導される．今回我々は，表皮への代表的な外的刺激であるウイルス感染と紫外線がヒト表皮細胞でのRIG-I発現に与える影響について検討した．擬似的ウイルス感染を生じるpolyinosinic-polycytidylic acidを用いてヒト表皮細胞を刺激するとRIG-Iの発現増強が認められたが，この発現増強と非刺激時のRIG-I基礎発現量は中波長紫外線（UVB）照射によって抑制された．このことよりUVB がRIG-I発現抑制を介して皮膚免疫の低下を促し，皮膚におけるウイルス感染やその再活性化の誘導に関与している可能性が示唆された．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62(1), 2011, p.1-6","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11664","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11161","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツザキ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12672","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キタムラ, ヒデオ"}]},{"nameIdentifiers":[{"nameIdentifier":"12673","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アカサカ, エイジロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"12674","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ロクノヘ, ダイキ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, 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Daisuke"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.3","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科附属脳神経血管病態研究施設脳血管病態学講座"},{"subitem_text_value":"弘前大学大学院医学研究科附属脳神経血管病態研究施設脳血管病態学講座"},{"subitem_text_value":"弘前大学大学院医学研究科皮膚科学講座"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Vascular Biology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Dermatology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"木村, 一之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松崎, 康司"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"北村, 英夫"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"赤坂, 英二郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"六戸, 大樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中野, 創"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"今泉, 忠淳"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"佐藤, 敬"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤村, 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