{"created":"2023-05-15T09:02:50.107142+00:00","id":3720,"links":{},"metadata":{"_buckets":{"deposit":"8af236c6-abca-4a67-8e26-0e3891e42069"},"_deposit":{"created_by":3,"id":"3720","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3720"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003720","sets":["557:561:648"]},"author_link":["12736","11982","12732","11980","12011","12745","12747","12019","12724","11875","12740","12722","12028","12010","11976","12731","12047","12014","12730","12037","12734","11987","12741","12020","12721","12729","12742","11989","11994","12743","12719","12015","12720"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"p38 MAP kinase の抑制はマウスの圧負荷による病的心肥大を軽減し心機能低下を抑制する"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"p38 MAP kinase ノ ヨクセイ ワ マウス ノ アツフカ ニヨル ビョウテキ シンヒダイ オ ケイゲンシ シンキノウ テイカ オ ヨクセイ スル"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"26","bibliographicPageStart":"18","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background: P38 mitogen-activated protein kinase（MAP kinase）plays on important role for progression of pathological cardiac hypertrophy. However, the role of p38 MAP kinase in cardiac hypertrophy induced by pressure overload remains unclear. We investigated the effect of chronic treatment with p38 MAP kinase inhibitor on the development of heart failure induced by transverse aortic constriction（TAC）in mice. Methods and Results: TAC increased left ventricular septal wall thickness（LVSWT）and cross-sectional area（CSA）of cardiomyocyte, and decreased LV fractional shortening（FS）compared with sham operation after 6 weeks. TAC also increased phosphorylation of p38 MAP kinase, whereas other hypertrophic signals were unchanged. In another experiment, TAC mice and sham operated mice were treated with subcutaneous injection of p38 MAP kinase inhibitor SB202190（5mg/kg/day）or placebo five times a week for six weeks. Treatment with p38 MAP kinase inhibitor attenuated the increase in LVSWT and CSA, and the decrease in FS in mice with TAC.\nConclusions: Inhibition of p38 MAP kinase attenuated left ventricular hypertrophy and inhibited progression of systolic dysfunction in pressure overload-induced cardiac hypertrophy. These results suggest that inhibition of p38 MAP kinase has a protective effect for development of heart failure induced by pressure overload.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62(1), 2011, p.18-26","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12015","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, ケンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12729","nameIdentifierScheme":"WEKO"}],"names":[{"name":"スケカワ, タカノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"12730","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオヤ, フミエ"}]},{"nameIdentifiers":[{"nameIdentifier":"12731","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イズミヤマ, ケイ"}]},{"nameIdentifiers":[{"nameIdentifier":"12732","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サガラ, シゲキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12037","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, タイヘイ"}]},{"nameIdentifiers":[{"nameIdentifier":"12734","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマモト, ユウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12014","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シブタニ, シュウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12736","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トミタ, ヒロフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12020","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 賢二"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"12740","nameIdentifierScheme":"WEKO"}],"names":[{"name":"祐川, 誉徳"}]},{"nameIdentifiers":[{"nameIdentifier":"12741","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大矢, 史恵"}]},{"nameIdentifiers":[{"nameIdentifier":"12742","nameIdentifierScheme":"WEKO"}],"names":[{"name":"泉山, 圭"}]},{"nameIdentifiers":[{"nameIdentifier":"12743","nameIdentifierScheme":"WEKO"}],"names":[{"name":"相樂, 繁樹"}]},{"nameIdentifiers":[{"nameIdentifier":"12047","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 太平"}]},{"nameIdentifiers":[{"nameIdentifier":"12745","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山本, 祐子"}]},{"nameIdentifiers":[{"nameIdentifier":"12019","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渋谷, 修司"}]},{"nameIdentifiers":[{"nameIdentifier":"12747","nameIdentifierScheme":"WEKO"}],"names":[{"name":"富田, 泰史"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.2","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hanada, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sukekawa, Takanori"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohya, Fumie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumiyama, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagara, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Taihei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Shibutani, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(1)_18.pdf","filesize":[{"value":"938.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(1)_18.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3720/files/HirosakiMedJ_62(1)_18.pdf"},"version_id":"f8011cdb-d0fa-48b6-97e7-763027493243"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"p38 MAP kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"cardiac hypertrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"transverse aortic constriction","subitem_subject_scheme":"Other"},{"subitem_subject":"心肥大","subitem_subject_scheme":"Other"},{"subitem_subject":"大動脈縮窄術","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice"}]},"item_type_id":"3","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-18"},"publish_date":"2011-03-18","publish_status":"0","recid":"3720","relation_version_is_last":true,"title":["Inhibition of P38 MAP Kinase Attenuates Left Ventricular Hypertrophy and Inhibits Progression of Systolic Dysfunction on Pressure-Overload Induced Pathological Cardiac Hypertrophy in Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:42:50.866462+00:00"}