{"created":"2023-05-15T09:02:50.149503+00:00","id":3721,"links":{},"metadata":{"_buckets":{"deposit":"13c60125-1be4-4ebd-9d20-94230d8aa419"},"_deposit":{"created_by":3,"id":"3721","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3721"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003721","sets":["557:561:648"]},"author_link":["12736","11982","12732","11980","12011","12745","12747","12019","12724","11875","12010","12722","11976","12731","12014","12730","12734","11987","12741","12020","12721","12742","11989","11994","12743","12015","12720"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"日本人冠攣縮性狭心症患者における ABCC9 遺伝子変異の有無の解析"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ニホンジン カンレン シュクセイ キョウシンショウ カンジャ ニオケル ABCC9 イデンシ ヘンイ ノ ウム ノ カイセキ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"33","bibliographicPageStart":"27","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Coronary artery spasm plays an important role in the etiology of coronary spastic angina（CSA）and other acute coronary syndromes. Mice with a targeted disruption of the ATP-binding cassette transporter C9‒ABCC9 gene were developed as an animal model of CSA. Thus, the ABCC9 may be involved in the regulation of coronary artery vasomotility. The aim of this study was to investigate whether mutation in the coding region of the ABCC9 gene is detected in Japanese patients with CSA. The study included 9 Japanese patients with CSA （6 men and 3 women with a mean age of 51±13 years）. Genomic DNA was extracted from the whole blood, and Mutation analysis of the coding region of ABCC9 was performed by direct sequencing. In one CSA patient, we found a single base substitution（G to A）at nucleotide position 126 in exon 21 of the coding region, which was heterozygous and did not cause amino acid substitution（T878T, silent mutation）.In the remaining 8 patients, no base substitution was\ndetected in the coding region of the ABCC9 gene. The results indicate that the mutation of the ABCC9 gene may not be involved in the genetic pathogenesis of CSA in humans.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62(1), 2011, p.27-33","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12014","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シブタニ, シュウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オサナイ, トモヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12730","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オオヤ, フミエ"}]},{"nameIdentifiers":[{"nameIdentifier":"12732","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サガラ, シゲキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12731","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イズミヤマ, ケイ"}]},{"nameIdentifiers":[{"nameIdentifier":"12734","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマモト, ユウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12015","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, ケンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"12736","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トミタ, ヒロフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12019","nameIdentifierScheme":"WEKO"}],"names":[{"name":"渋谷, 修司"}]},{"nameIdentifiers":[{"nameIdentifier":"11989","nameIdentifierScheme":"WEKO"}],"names":[{"name":"長内, 智宏"}]},{"nameIdentifiers":[{"nameIdentifier":"12741","nameIdentifierScheme":"WEKO"}],"names":[{"name":"大矢, 史恵"}]},{"nameIdentifiers":[{"nameIdentifier":"12743","nameIdentifierScheme":"WEKO"}],"names":[{"name":"相樂, 繁樹"}]},{"nameIdentifiers":[{"nameIdentifier":"12742","nameIdentifierScheme":"WEKO"}],"names":[{"name":"泉山, 圭"}]},{"nameIdentifiers":[{"nameIdentifier":"12745","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山本, 祐子"}]},{"nameIdentifiers":[{"nameIdentifier":"12020","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 賢二"}]},{"nameIdentifiers":[{"nameIdentifier":"12747","nameIdentifierScheme":"WEKO"}],"names":[{"name":"富田, 泰史"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.2","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"},{"subitem_text_value":"弘前大学大学院医学研究科循環呼吸腎臓内科学"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shibutani, Shuji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Osanai, Tomohiro"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ohya, Fumie"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sagara, Shigeki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Izumiyama, Kei"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamamoto, Yuko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hanada, Kenji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Tomita, Hirofumi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(1)_27.pdf","filesize":[{"value":"752.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(1)_27.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3721/files/HirosakiMedJ_62(1)_27.pdf"},"version_id":"afe174eb-5eff-4153-be13-53c8c17fe52e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"vasospasm","subitem_subject_scheme":"Other"},{"subitem_subject":"ABCC9","subitem_subject_scheme":"Other"},{"subitem_subject":"mutation","subitem_subject_scheme":"Other"},{"subitem_subject":"冠攣縮性狭心症","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子変異","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina"}]},"item_type_id":"3","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-18"},"publish_date":"2011-03-18","publish_status":"0","recid":"3721","relation_version_is_last":true,"title":["Mutation Analysis ABCC9 Gene in Japanese Patients with Coronary Spastic Angina"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:42:51.228928+00:00"}