{"created":"2023-05-15T09:02:50.275728+00:00","id":3724,"links":{},"metadata":{"_buckets":{"deposit":"ae14fc12-28d5-419b-9165-fe2aa4ef9cac"},"_deposit":{"created_by":3,"id":"3724","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3724"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003724","sets":["557:561:648"]},"author_link":["12817","12815","11855","12816","12820","12821","12251","12259","12818"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"MDMAの類縁体であるmethyloneの行動毒性および依存性に対する影響について"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"MDMA ノ ルイエンタイ デアル methylone ノ コウドウ ドクセイ オヨビ イゾンセイ ニ タイスル エイキョウ ニツイテ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"71","bibliographicPageStart":"56","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Methylone, an analog of 3,4-methylenedioxymethamphetamine（MDMA）is a narcotic drug which is forbidden due to its abusability. However, a detailed behavioral toxicity and rewarding effect of methylone has not yet been reported to this date. The aim of this study is to evaluate the toxicity and addictive effects of methylone. In order to detect the stimulant effect to central nerous system, a mouse behavioral toxicity test and a conditioned place preference（CPP）test were conducted by administering mehtylone, MDMA and methamphetamine（MAP）.An immunohistochemical study was also performed to analyze ΔFosB, which is known to accumulate in the nucleus accumbens after chronic administration of the drugs of abuse. For determining the expression levels of ΔfosB mRNA in striatum, quantitative PCR analysis was also conducted by acute administration of methylone. Significant differences appeared in mice that were administered with 50 mg/kg and above of methylone. Methylone causes a similar qualitative behavioral effect as MAP, however not the same stereotyped behavior as MDMA. According to the result from CPP test, methylone of 2.5 mg/kg and above had shown a rewarding action. Chronic administration of methylone causes significant ΔFosB accumulation in the neurons of nucleus accumbens. Methylone and MDMA significantly induce ΔfosB mRNA in striatum. It is therefore suggested that methylone has psychoactive effects and can be considered as an addictive drug.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62(1), 2011, p.56-71","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12817","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミヤザワ, マキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12818","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コジマ, タカシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12251","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカジ, シゲユキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12820","nameIdentifierScheme":"WEKO"}],"names":[{"name":"宮澤, 眞紀"}]},{"nameIdentifiers":[{"nameIdentifier":"12821","nameIdentifierScheme":"WEKO"}],"names":[{"name":"小島, 尚"}]},{"nameIdentifiers":[{"nameIdentifier":"12259","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中路, 重之"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.5","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine・Kanagawa Prefectural Institute of public Health"},{"subitem_text_value":"Kanagawa Prefectural Institute of public Health"},{"subitem_text_value":"Department of Social Medicine, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科社会医学講座・神奈川県衛生研究所"},{"subitem_text_value":"神奈川県衛生研究所"},{"subitem_text_value":"弘前大学大学院医学研究科社会医学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyazawa, Maki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kojima, Takashi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakaji, Shigeyuki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(1)_56.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(1)_56.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3724/files/HirosakiMedJ_62(1)_56.pdf"},"version_id":"ee2f5b86-94ab-4f60-b323-7f3241a6f009"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"methylone","subitem_subject_scheme":"Other"},{"subitem_subject":"MDMA","subitem_subject_scheme":"Other"},{"subitem_subject":"behavioral effect","subitem_subject_scheme":"Other"},{"subitem_subject":"rewarding effect","subitem_subject_scheme":"Other"},{"subitem_subject":"Δ FosB","subitem_subject_scheme":"Other"},{"subitem_subject":"行動影響","subitem_subject_scheme":"Other"},{"subitem_subject":"報酬効果","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Behavioral and Rewarding Effects of Methylone, an Analog of MDMA in Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Behavioral and Rewarding Effects of Methylone, an Analog of MDMA in Mice"}]},"item_type_id":"3","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-22"},"publish_date":"2011-03-22","publish_status":"0","recid":"3724","relation_version_is_last":true,"title":["Behavioral and Rewarding Effects of Methylone, an Analog of MDMA in Mice"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T12:06:47.692498+00:00"}