{"created":"2023-05-15T09:02:50.317611+00:00","id":3726,"links":{},"metadata":{"_buckets":{"deposit":"c2cc3d7e-b3a3-4f9f-8733-9cb5283bfc6e"},"_deposit":{"created_by":3,"id":"3726","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3726"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003726","sets":["557:561:648"]},"author_link":["11107","12841","12846","12848","12570","12850","12855","12843","12840","12844","12565","12851","12562","11095","12839","12842","12853","11101","12857","10995"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"<症例研究>S-1によるワーファリン抗凝固作用の増強"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ショウレイ ケンキュウ S-1 ニヨル ワーファリン コウギョウコ サヨウ ノ ゾウキョウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"85","bibliographicPageStart":"80","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"S-1, an oral prodrug of 5-fluorouracil, has been employed in treatment of solid tumors in Japan. We report two patient cases whose international normalized ratio（INR）increased due to concomitant treatment with warfarin and S-1. In case 1, a 63-year-old man, who had taken 3.5 mg/day warfarin for dilated cardiomyopathy, had a subcutaneous hematoma in a left lower eyelid on the ninth course of combination chemotherapy with S-1 and docetaxel for metastatic gastric cancer. His INR increased to 3.68 despite careful monitoring of coagulation parameters. In case 2, a 68-year-old man, who received combination chemotherapy with S-1 and irinotecan for metastatic colorectal cancer, had to reduce the dose of warfarin twice during the same chemotherapy courses because of repeated prolongation of INR. We speculate that multiple mechanisms of unstable INR are involved in strengthening the anticoagulant effect of warfarin. Frequent monitoring of INR is required to prevent unexpected adverse events of coagulation abnormality induced by the interaction between S-1 and warfarin．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62(1), 2011, p.80-85","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テルイ, カズフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"10995","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タカハタ, タケノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"12846","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, ジュンヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"11101","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシグロ, アツシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12848","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, ジュウゴウ"}]},{"nameIdentifiers":[{"nameIdentifier":"12565","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤカリ, マコト"}]},{"nameIdentifiers":[{"nameIdentifier":"12850","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サイジョウ, ヤスオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12851","nameIdentifierScheme":"WEKO"}],"names":[{"name":"照井, 一史"}]},{"nameIdentifiers":[{"nameIdentifier":"10995","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高畑, 武功"}]},{"nameIdentifiers":[{"nameIdentifier":"12853","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 淳也"}]},{"nameIdentifiers":[{"nameIdentifier":"11095","nameIdentifierScheme":"WEKO"}],"names":[{"name":"石黒, 敦"}]},{"nameIdentifiers":[{"nameIdentifier":"12855","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊東, 重豪"}]},{"nameIdentifiers":[{"nameIdentifier":"12570","nameIdentifierScheme":"WEKO"}],"names":[{"name":"早狩, 誠"}]},{"nameIdentifiers":[{"nameIdentifier":"12857","nameIdentifierScheme":"WEKO"}],"names":[{"name":"西條, 康夫"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学出版会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"492.3","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Division of Pharmacy，Hirosaki University Hospital"},{"subitem_text_value":"Department of Medical Oncology，Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Division of Pharmacy，Hirosaki University Hospital"},{"subitem_text_value":"Department of Medical Oncology，Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Medical Oncology，Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Division of Pharmacy，Hirosaki University Hospital"},{"subitem_text_value":"Department of Medical Oncology，Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科薬剤学講座"},{"subitem_text_value":"弘前大学大学院医学研究科腫瘍内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科薬剤学講座"},{"subitem_text_value":"弘前大学大学院医学研究科腫瘍内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科腫瘍内科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科薬剤学講座"},{"subitem_text_value":"弘前大学大学院医学研究科腫瘍内科学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Terui, Kazufumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takahata, Takenori"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Sato, Junya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishiguro, Atsushi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Itoh, Jugoh"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayakari, Makoto"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Saijo, Yasuo"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(1)_80.pdf","filesize":[{"value":"860.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(1)_80.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3726/files/HirosakiMedJ_62(1)_80.pdf"},"version_id":"3b13aa5e-7f07-4d05-95a1-13f4fa74c966"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"coagulation","subitem_subject_scheme":"Other"},{"subitem_subject":"S-1","subitem_subject_scheme":"Other"},{"subitem_subject":"warfarin","subitem_subject_scheme":"Other"},{"subitem_subject":"相互作用","subitem_subject_scheme":"Other"},{"subitem_subject":"ワーファリン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Case Study>Enhancement of Warfarin Anticoagulant Activity by S-1","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Case Study>Enhancement of Warfarin Anticoagulant Activity by S-1"}]},"item_type_id":"3","owner":"3","path":["648"],"pubdate":{"attribute_name":"公開日","attribute_value":"2011-03-22"},"publish_date":"2011-03-22","publish_status":"0","recid":"3726","relation_version_is_last":true,"title":["<Case Study>Enhancement of Warfarin Anticoagulant Activity by S-1"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:46:56.342266+00:00"}