{"created":"2023-05-15T09:02:50.402774+00:00","id":3728,"links":{},"metadata":{"_buckets":{"deposit":"9918221e-2490-4158-9234-d622110fbd82"},"_deposit":{"created_by":3,"id":"3728","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3728"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003728","sets":["557:561:649"]},"author_link":["12100","11298","10707","11713","12875","11294","12093","11717","11707","11712","12086","10708","10706","11290","12092","11718","12087","11708"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"コラーゲン・トリペプチドおよびヒアルロン酸関節内投与における変形性膝関節症予防効果の比較"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コラーゲン トリペプチド オヨビ ヒアルロンサン カンセツナイ トウヨ ニオケル ヘンケイセイ ヒザ カンセツショウ ヨボウ コウカ ノ ヒカク"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"116","bibliographicPageStart":"107","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Abstract　Objective Collagen peptides have recently been shown to have several biological activities, and have been used as preservatives and immunotherapeutic agents. The purpose of this study was to investigate the ability of weekly intra-rticular injections of collagen tripeptide （Ctp） to prevent knee osteoarthritis （OA） compared with sodium hyaluronan（ HA）.\nMethods Thirty rabbits with anterior cruciate ligament（ ACL） transection were randomly divided into three groups: Ctp, HA, and saline（ control）. All animals were administered the same amount of each reagent once weekly. Articular cartilages of the medial condyle of femur were examined by gross morphological and histopathological examination conducted at 5（ n=6） and 10（ n=4） weeks.\nResults The Ctp and HA injection groups tended to have improved gross morphological scores and exhibited preventive effects compared with control groups at 10 weeks after ACL transection. But the scores were not significantly different among the 3 groups. The overall means of histological grading scores were not significantly different among the 3 groups however, the score for the Ctp group had improved from 5 weeks to 10 weeks.\nConclusions Intra-articular injections of Ctp may inhibit progression of knee OA, and further examination is needed to clarify the physical characteristics and regenerative functions of Ctp, and to determine the optimal dose and duration of Ctp injection therapy for the knee OA.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62, 2011, p.107-116","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11712","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナラオカ, タクヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"10707","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イシバシ, ヤスユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12092","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツダ, エイイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"12093","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマモト, ユウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11298","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クスミ, トモミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11713","nameIdentifierScheme":"WEKO"}],"names":[{"name":"トウ, サトシ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"11717","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奈良岡, 琢哉"}]},{"nameIdentifiers":[{"nameIdentifier":"10706","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"263","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/263_ja.html"}],"names":[{"name":"石橋, 恭之"}]},{"nameIdentifiers":[{"nameIdentifier":"12875","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"458","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/458_ja.html"}],"names":[{"name":"津田, 英一"}]},{"nameIdentifiers":[{"nameIdentifier":"12100","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"100000222","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/100000222_ja.html"}],"names":[{"name":"山本, 祐司"}]},{"nameIdentifiers":[{"nameIdentifier":"11294","nameIdentifierScheme":"WEKO"}],"names":[{"name":"楠美, 智巳"}]},{"nameIdentifiers":[{"nameIdentifier":"11718","nameIdentifierScheme":"WEKO"}],"names":[{"name":"藤, 哲"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"490","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科整形外科学講座"},{"subitem_text_value":"弘前大学大学院医学研究科病理学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Naraoka, Takuya"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ishibashi, Yasuyuki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tsuda, Eiichi"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Yamamoto, Yuji"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Kusumi, Tomomi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Toh, Satoshi"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(2-4)_107.pdf","filesize":[{"value":"755.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(2-4)_107.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3728/files/HirosakiMedJ_62(2-4)_107.pdf"},"version_id":"3ca30846-bee4-4b7c-b6da-ad2ef0ef7279"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"変形性膝関節症","subitem_subject_scheme":"Other"},{"subitem_subject":"コラーゲンペプチド","subitem_subject_scheme":"Other"},{"subitem_subject":"ヒアルロン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"軟骨","subitem_subject_scheme":"Other"},{"subitem_subject":"注射","subitem_subject_scheme":"Other"},{"subitem_subject":"Osteoarthritis","subitem_subject_scheme":"Other"},{"subitem_subject":"collagen peptide","subitem_subject_scheme":"Other"},{"subitem_subject":"hyaluronic acid","subitem_subject_scheme":"Other"},{"subitem_subject":"cartilage","subitem_subject_scheme":"Other"},{"subitem_subject":"injection","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparison between the Effect of Collagen Tripeptide and Sodium Hyaluronan to Prevent Knee Osteoarthritis : A Preliminary in vivo Study","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparison between the Effect of Collagen Tripeptide and Sodium Hyaluronan to Prevent Knee Osteoarthritis : A Preliminary in vivo Study"}]},"item_type_id":"3","owner":"3","path":["649"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-12"},"publish_date":"2012-01-12","publish_status":"0","recid":"3728","relation_version_is_last":true,"title":["Comparison between the Effect of Collagen Tripeptide and Sodium Hyaluronan to Prevent Knee Osteoarthritis : A Preliminary in vivo Study"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:08:26.216448+00:00"}