{"created":"2023-05-15T09:02:50.659992+00:00","id":3732,"links":{},"metadata":{"_buckets":{"deposit":"790110cd-59c3-4a66-84f6-31da9bbd4b28"},"_deposit":{"created_by":3,"id":"3732","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3732"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003732","sets":["557:561:649"]},"author_link":["12949","12946","11662","12683","12673","11163","11671","12668","12936","11147","12939","12682","12933","12942","12674","12669","11531","11517","11664","11155","11524"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The Interaction of Photo Protective Effects between Keratinocytes and Melanocytes via Endothelin-1/Stem Cell Factor Signalings"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル(ヨミ)","attribute_value_mlt":[{"subitem_alternative_title":"シガイセン ボウギョ キコウ ニオケル メラノサイト ケラチノサイト ノ エンドセリン-1 カンサイボウ インシ オ カイシタ ソウゴ サヨウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"143","bibliographicPageStart":"138","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"皮膚の紫外線防御において中心的な役割を担っているのはメラニンである.エンドセリン-1(ET-1),幹細胞因子(SCF)はUVB 照射時にケラチノサイトから分泌され,メラニン合成を促進する.本研究では正常ヒトメラノサイト(NHM)においてET-1,SCF によりUVB 照射による細胞死が減少することを解明し,そのメカニズムについて検討した.ET-1,SCF 添加によりNHM において生体防御因子の一つであるヘムオキシゲナーゼ-1(HO-1)発現が誘導された.ET-1/SCF はメラニン産生を介してケラチノサイトを防御し,HO-1 を介してメラノサイトの紫外線防御にも関与しており,皮膚紫外線防御機構にはET-1/SCF を介したメラノサイト,ケラチノサイトの相互作用があると考えられた.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62, 2011, p.138-143","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12673","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アカサカ, エイジロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"12939","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ジン, カヨ"}]},{"nameIdentifiers":[{"nameIdentifier":"11664","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12674","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ロクノヘ, ダイキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12942","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イモカワ, ゲンジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11524","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サワムラ, ダイスケ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12682","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Akasaka, Eijiro"}]},{"nameIdentifiers":[{"nameIdentifier":"11147","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"269","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/269_ja.html"}],"names":[{"name":"Nakano, Hajime"}]},{"nameIdentifiers":[{"nameIdentifier":"12946","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Jin, Kayo"}]},{"nameIdentifiers":[{"nameIdentifier":"11671","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kimura, Kazuyuki"}]},{"nameIdentifiers":[{"nameIdentifier":"12683","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Rokunohe, Daiki"}]},{"nameIdentifiers":[{"nameIdentifier":"12949","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Imokawa, Genji"}]},{"nameIdentifiers":[{"nameIdentifier":"11517","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}],"names":[{"name":"Sawamura, Daisuke"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"494.8","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"外科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科"},{"subitem_text_value":"東京工科大学"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"赤坂, 英二郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"中野, 創"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"神, 可代"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"木村, 一之"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"六戸, 大樹"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"芋川, 玄爾"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"澤村, 大輔"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(2-4)_138.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(2-4)_138.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3732/files/HirosakiMedJ_62(2-4)_138.pdf"},"version_id":"4b523200-2894-43ef-aed2-df8a4abfa504"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ヘムオキシゲナーゼ-1","subitem_subject_scheme":"Other"},{"subitem_subject":"エンドセリン-1","subitem_subject_scheme":"Other"},{"subitem_subject":"幹細胞因子","subitem_subject_scheme":"Other"},{"subitem_subject":"メラノサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"紫外線防御","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"紫外線防御機構におけるメラノサイト, ケラチノサイトのエンドセリン-1 / 幹細胞因子を介した相互作用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"紫外線防御機構におけるメラノサイト, ケラチノサイトのエンドセリン-1 / 幹細胞因子を介した相互作用"}]},"item_type_id":"3","owner":"3","path":["649"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-12"},"publish_date":"2012-01-12","publish_status":"0","recid":"3732","relation_version_is_last":true,"title":["紫外線防御機構におけるメラノサイト, ケラチノサイトのエンドセリン-1 / 幹細胞因子を介した相互作用"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:20:23.595082+00:00"}