{"created":"2023-05-15T09:02:50.788127+00:00","id":3734,"links":{},"metadata":{"_buckets":{"deposit":"2cd5f4e9-6fd0-44cf-a712-cc5a20753e54"},"_deposit":{"created_by":3,"id":"3734","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3734"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003734","sets":["557:561:649"]},"author_link":["12990","11163","11158","12978","12991","12993","12982","11147","12981","11328","12985","12983","11330","11166","12992","12984","12980","11531","11517","11150","11326","12979","11155","11524"],"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"マウス ヒョウヒ デノ ヒョウヒ カクカ サイボウブンカ ニ オケル Raf kinase inhibitor protein ノ ハツゲン"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12-26","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"172","bibliographicPageStart":"166","bibliographicVolumeNumber":"62","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"　Raf kinase inhibitor protein（ RKIP） has been demonstrated to bind to Raf-1 and mitogen-activated proteinkinase kinase （MEK） and to inhibit the mitogen-activated protein kinase （MAPK） signaling pathway. Recently,we have discovered that introduction of the RKIP gene into human keratinocytes induces differentiation. In thisstudy, we first examined expression of RKIP in the mouse epidermis in vivo and found that RKIP was expressed inall keratinocyte layers. However, western blot analysis clearly showed that differentiated keratinocytes expressedmore RKIP than undifferentiated keratinocytes. These data indicated that RKIP expression in the mouse epidermisincreased with keratinocyte differentiation. As 1????,25-dihydoxyvitamin D3 （1,25（OH）2D3） suppresses keratinocyteproliferation and promotes differentiation, we next examined the effect of 1,25（OH）2D3 on RKIP expression and foundthat 1,25（OH）2D3 increased mRNA and protein expression of RKIP in cultured mouse keratinocytes. These resultssuggest that 1,25（OH）2D3-induced keratinocyte differentiation may be mediated by induction of RKIP expression.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 62, 2011, p.166-172","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12982","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イケナガ, サツキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12983","nameIdentifierScheme":"WEKO"}],"names":[{"name":"アイヅ, タカユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12984","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カンベ, ユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12985","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ヤマザキ, タケヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, ハジメ"}]},{"nameIdentifiers":[{"nameIdentifier":"11166","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハナダ, カツミ"}]},{"nameIdentifiers":[{"nameIdentifier":"11524","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サワムラ, ダイスケ"}]},{"nameIdentifiers":[{"nameIdentifier":"11328","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツチダ, シゲキ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12990","nameIdentifierScheme":"WEKO"}],"names":[{"name":"池永, 五月"}]},{"nameIdentifiers":[{"nameIdentifier":"12991","nameIdentifierScheme":"WEKO"}],"names":[{"name":"会津, 隆幸"}]},{"nameIdentifiers":[{"nameIdentifier":"12992","nameIdentifierScheme":"WEKO"}],"names":[{"name":"神戸, 有希"}]},{"nameIdentifiers":[{"nameIdentifier":"12993","nameIdentifierScheme":"WEKO"}],"names":[{"name":"山崎, 尊彦"}]},{"nameIdentifiers":[{"nameIdentifier":"11155","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 創"}]},{"nameIdentifiers":[{"nameIdentifier":"11158","nameIdentifierScheme":"WEKO"}],"names":[{"name":"花田, 勝美"}]},{"nameIdentifiers":[{"nameIdentifier":"11531","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"268","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/268_ja.html"}],"names":[{"name":"澤村, 大輔"}]},{"nameIdentifiers":[{"nameIdentifier":"11326","nameIdentifierScheme":"WEKO"}],"names":[{"name":"土田, 成紀"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院医学研究科"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ikenaga, Satsuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Aizu, Takayuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kambe, Yuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Yamazaki, Takehiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Hajime"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Hanada, Katsumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sawamura, Daisuke"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Tsuchida, Shigeki"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_62(2-4)_166.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_62(2-4)_166.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3734/files/HirosakiMedJ_62(2-4)_166.pdf"},"version_id":"7228763f-84d2-4165-b2ff-109eb08b6869"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"keratinocytes","subitem_subject_scheme":"Other"},{"subitem_subject":"signal transduction","subitem_subject_scheme":"Other"},{"subitem_subject":"differentiation","subitem_subject_scheme":"Other"},{"subitem_subject":"vitamin D","subitem_subject_scheme":"Other"},{"subitem_subject":"表皮角化細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"シグナル伝達","subitem_subject_scheme":"Other"},{"subitem_subject":"分化","subitem_subject_scheme":"Other"},{"subitem_subject":"ビタミンD","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression of Raf Kinase Inhibitor Protein in Keratinocyte Differentiation in the Mouse Epidermis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression of Raf Kinase Inhibitor Protein in Keratinocyte Differentiation in the Mouse Epidermis"}]},"item_type_id":"3","owner":"3","path":["649"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-01-13"},"publish_date":"2012-01-13","publish_status":"0","recid":"3734","relation_version_is_last":true,"title":["Expression of Raf Kinase Inhibitor Protein in Keratinocyte Differentiation in the Mouse Epidermis"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:48:04.370213+00:00"}