@article{oai:hirosaki.repo.nii.ac.jp:00003740,
 author = {Nakamura, Kunihiko and Mikuniya, Megumi and Takanashi, Shingo and Hayashi, Akihito and Morimoto, Takeshi and Taima, Kageaki and Dempoya, Junichi and Okumura, Ken},
 issue = {1},
 journal = {弘前医学},
 month = {May},
 note = {Introduction: Although analysis of bronchoalveolar lavage fluid （BALF） is a useful examination to assess airway inflammation, it is an invasive technique with limitation and risk of complications.
Objectives: The aim of this study was to examine molecules in exhaled breath condensate（ EBC） in comparison with BALF, and to clarify the clinical usability of EBC.
Methods: EBC was collected from sixteen subjects suspected to have sarcoidosis just before BAL. The 40 different inflammatory molecules in EBC and BALF were analyzed by protein array.
Results: BALF levels of 6 molecules including soluble tumor necrosis factor receptor type II （sTNF-RII） and regulated upon activation, normal T cell expressed and secreted （RANTES）, and EBC levels of 13 molecules including sTNF-RII and RANTES were significantly correlated with percentage of lymphocyte in BALF （%Lym）. We found significant correlations between levels of EBC and BALF in 16 out of 40 molecules. Levels of macrophage colony-stimulating factor（ M-CSF）, RANTES, TNF-α and sTNF-RII in EBC were significantly correlated with BALF. Their levels in EBC and BALF also were correlated with %Lym.
Conclusion: Protein array, a highly sensitive approach allowed us to detect inflammatory molecules in EBC. Comprehensive analysis of EBC might be an equivalent to that of BALF., 弘前医学. 63, 2012, p.12-20},
 pages = {12--20},
 title = {Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?},
 volume = {63},
 year = {2012}
}