{"created":"2023-05-15T09:02:51.180010+00:00","id":3740,"links":{},"metadata":{"_buckets":{"deposit":"008cd770-0c41-40a0-b6f2-95f5a6d7e12f"},"_deposit":{"created_by":3,"id":"3740","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3740"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003740","sets":["557:561:650"]},"author_link":["12911","12928","12924","11874","12923","11875","11987","12930","12906","12907","12910","12919","12913","12920","12917","12914","12929","12916","12918","12926","12927","11994","12909","11867"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"呼気凝縮液の有用性に関する研究 : 気管支肺胞洗浄液との比較検討"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"コキ ギョウシュク エキ ノ ユウヨウセイ ニ カンスル ケンキュウ キカンシ ハイホウ センジョウ エキ トノ ヒカク ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"20","bibliographicPageStart":"12","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Introduction: Although analysis of bronchoalveolar lavage fluid （BALF） is a useful examination to assess airway inflammation, it is an invasive technique with limitation and risk of complications.\nObjectives: The aim of this study was to examine molecules in exhaled breath condensate（ EBC） in comparison with BALF, and to clarify the clinical usability of EBC.\nMethods: EBC was collected from sixteen subjects suspected to have sarcoidosis just before BAL. The 40 different inflammatory molecules in EBC and BALF were analyzed by protein array.\nResults: BALF levels of 6 molecules including soluble tumor necrosis factor receptor type II （sTNF-RII） and regulated upon activation, normal T cell expressed and secreted （RANTES）, and EBC levels of 13 molecules including sTNF-RII and RANTES were significantly correlated with percentage of lymphocyte in BALF （%Lym）. We found significant correlations between levels of EBC and BALF in 16 out of 40 molecules. Levels of macrophage colony-stimulating factor（ M-CSF）, RANTES, TNF-α and sTNF-RII in EBC were significantly correlated with BALF. Their levels in EBC and BALF also were correlated with %Lym.\nConclusion: Protein array, a highly sensitive approach allowed us to detect inflammatory molecules in EBC. Comprehensive analysis of EBC might be an equivalent to that of BALF.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 63, 2012, p.12-20","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12914","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカムラ, クニヒコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12913","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ミクニヤ, メグミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12916","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タカナシ, シンゴ"}]},{"nameIdentifiers":[{"nameIdentifier":"12917","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤシ, アキヒト"}]},{"nameIdentifiers":[{"nameIdentifier":"12918","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モリモト, タケシ"}]},{"nameIdentifiers":[{"nameIdentifier":"12919","nameIdentifierScheme":"WEKO"}],"names":[{"name":"タイマ, カゲアキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12920","nameIdentifierScheme":"WEKO"}],"names":[{"name":"デンポウヤ, ジュンイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"11987","nameIdentifierScheme":"WEKO"}],"names":[{"name":"オクムラ, ケン"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12924","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中村, 邦彦"}]},{"nameIdentifiers":[{"nameIdentifier":"12923","nameIdentifierScheme":"WEKO"}],"names":[{"name":"三國谷, 恵"}]},{"nameIdentifiers":[{"nameIdentifier":"12926","nameIdentifierScheme":"WEKO"}],"names":[{"name":"高梨, 信吾"}]},{"nameIdentifiers":[{"nameIdentifier":"12927","nameIdentifierScheme":"WEKO"}],"names":[{"name":"林, 彰仁"}]},{"nameIdentifiers":[{"nameIdentifier":"12928","nameIdentifierScheme":"WEKO"}],"names":[{"name":"森本, 武史"}]},{"nameIdentifiers":[{"nameIdentifier":"12929","nameIdentifierScheme":"WEKO"}],"names":[{"name":"當麻, 景章"}]},{"nameIdentifiers":[{"nameIdentifier":"12930","nameIdentifierScheme":"WEKO"}],"names":[{"name":"傳法谷, 純一"}]},{"nameIdentifiers":[{"nameIdentifier":"11994","nameIdentifierScheme":"WEKO"}],"names":[{"name":"奥村, 謙"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.38","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学循環呼吸腎臓内科学講座"},{"subitem_text_value":"弘前大学保健管理センター"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nakamura, Kunihiko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Mikuniya, Megumi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Takanashi, Shingo"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Hayashi, Akihito"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morimoto, Takeshi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Taima, Kageaki"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Dempoya, Junichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Okumura, Ken"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_63(1)_12.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_63(1)_12.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3740/files/HirosakiMedJ_63(1)_12.pdf"},"version_id":"21c154ac-faee-46ad-bd77-02ea6110b061"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Inflammatory molecules","subitem_subject_scheme":"Other"},{"subitem_subject":"protein array analysis","subitem_subject_scheme":"Other"},{"subitem_subject":"sarcoidosis","subitem_subject_scheme":"Other"},{"subitem_subject":"exhaled breath condensate","subitem_subject_scheme":"Other"},{"subitem_subject":"bronchoalveolar lavage","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテイン・アレイ","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコイドーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"呼気凝縮液","subitem_subject_scheme":"Other"},{"subitem_subject":"気管支肺胞洗浄","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性サイトカイン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?"}]},"item_type_id":"3","owner":"3","path":["650"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-06-07"},"publish_date":"2012-06-07","publish_status":"0","recid":"3740","relation_version_is_last":true,"title":["Is Analysis of Exhaled Breath Condensate an Equivalent to Bronchoalveolar Lavage Fluid in Sarcoidos is Patients?"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T09:38:08.690615+00:00"}