{"created":"2023-05-15T09:02:51.245591+00:00","id":3741,"links":{},"metadata":{"_buckets":{"deposit":"3a8f0d11-29a3-4ec1-b3da-fafc97f7b2b2"},"_deposit":{"created_by":3,"id":"3741","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3741"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003741","sets":["557:561:650"]},"author_link":["11662","11672","11463","11163","12672","11447","13139","11671","11153","11147","13128","11451","11863","11458","11161","11449","12667","13131","11531","11456","11517","11664","11155","11524"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Relation between Retinoic ACID-INDUCIBLE GENE-I Expression and Cell Proliferation in Human Melanoma Cells"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト メラノーマ サイボウ ニオケル RETINOIC ACID-INDUCIBLE GENE-I ハツゲン トノ カンレン ト サイボウ ゾウショク"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-05-18","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"27","bibliographicPageStart":"21","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Retinoic acid-inducible gene-I （RIG-I）はウイルスの二本鎖RNA を認識すると1 型interferon （IFN）など多様な遺伝子の発現を誘導し，抗ウイルス作用を惹起する． 1 型IFN であるIFN-β はメラノーマにおける標準的な治療として有効性が確立されている．今回我々は，培養ヒトメラノーマ細胞を用いて，IFN-β 及び種々のサイトカインで刺激した際のRIG-I 発現および細胞増殖へ与える影響ついて検討した．各種培養ヒトメラノーマ細胞をIFN-β で刺激すると，多くの培養細胞ではRIG-I 発現が増強したが，唯一MeWo においてRIG-I 発現に変化がみられなかった．さらに，IFN-β添加においてRIG-I 発現能をもつ501mel では細胞増殖が抑制されたが，MeWo の細胞増殖能は不変であった．そこで，RIG-I 発現ベクターをMeWo に導入し，細胞増殖を検討した．その結果，MeWo 細胞の増殖はIFN-β により抑制され，RIG-I がIFN-β による細胞増殖抑制に重要な役割を担っていることが示唆された．このことよりヒトメラノーマ細胞にはRIG-I タンパク発現能をもたない群が存在すること，並びにメラノーマ組織別のRIG-I 発現レベルが，それをもつ患者のメラノーマに対してIFN-β がどのくらい効果をもつか決定する可能性が示唆された．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 63, 2012, p.21-27","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13131","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ニシカワ, ヨウヘイ"}]},{"nameIdentifiers":[{"nameIdentifier":"11161","nameIdentifierScheme":"WEKO"}],"names":[{"name":"マツザキ, ヤスシ"}]},{"nameIdentifiers":[{"nameIdentifier":"11664","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キムラ, カズユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12672","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キタムラ, ヒデオ"}]},{"nameIdentifiers":[{"nameIdentifier":"11163","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, 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