{"created":"2023-05-15T09:02:51.635426+00:00","id":3747,"links":{},"metadata":{"_buckets":{"deposit":"3b620477-405b-46ee-a507-e79d42d3afd5"},"_deposit":{"created_by":3,"id":"3747","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3747"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003747","sets":["557:561:651"]},"author_link":["12209","12199","13271","13278","13269","13272","12208","12204","13280","12203","13277","12198","13268","13273","13275"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"マウス腹腔マクロファージにおけるP2Y14受容体の発現と機能"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"マウス フクコウ マクロファージ ニオケル P2Y14 ジュヨウタイ ノ ハツゲン ト キノウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"104","bibliographicPageStart":"96","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The P2Y14 receptor is activated by UDP-glucose （UDPG）, which is a well-known glycosyl donor that participates in the biosynthesis of carbohydrates, and is widely expressed in immune cells. During inflammation and mechanical stress, damaged cells release nucleotides, including ATP and UDPG, as danger signals that act as P2Y receptor agonists. These nucleotide-induced signals participate in the regulation of immune responses. In this study, to investigate P2Y14 expression further, we performed flow cytometric analysis using an anti-P2Y14 monoclonal antibody. The results indicated that P2Y14 is expressed in murine immune cells, including T cells, B cells, monocytes, granulocytes, and CD11bhigh macrophages. Interestingly, the expression levels of P2Y14 differed between immature and mature monocytes, and in CD11bhigh macrophages, P2Y14 was gradually downregulated as peritonitis was terminated. The expression of CD11b is reduced by the efferocytosis of apoptotic neutrophils during peritonitis, and the induced CD11blow macrophages, which emerge in the resolution of peritonitis, play an important role in the termination of inflammation. Consistent with this observation, we revealed that administration of UDPG to mice with induced peritonitis increased the number of CD11blow macrophages. As P2Y14 is expressed in CD11bhigh macrophages but not in CD11blow macrophages, UDPG may participate in the conversion to the CD11blow phenotype. These data suggest a novel regulatory pathway of the inflammatory response via P2Y14 expressed on macrophages.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 63, 2012, p.96-104","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13272","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クドウ, フジミ"}]},{"nameIdentifiers":[{"nameIdentifier":"13273","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ニシグチ, ナオキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12203","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, キョウコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13275","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカノ, マナブ"}]},{"nameIdentifiers":[{"nameIdentifier":"12204","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イトウ, コウイチ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13277","nameIdentifierScheme":"WEKO"}],"names":[{"name":"工藤, 藤美"}]},{"nameIdentifiers":[{"nameIdentifier":"13278","nameIdentifierScheme":"WEKO"}],"names":[{"name":"西口, 直樹"}]},{"nameIdentifiers":[{"nameIdentifier":"12208","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 京子"}]},{"nameIdentifiers":[{"nameIdentifier":"13280","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中野, 学"}]},{"nameIdentifiers":[{"nameIdentifier":"12209","nameIdentifierScheme":"WEKO"}],"names":[{"name":"伊藤, 巧一"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"基礎医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学大学院保健学研究科生体機能科学"},{"subitem_text_value":"積水化学工業株式会社開発研究所"},{"subitem_text_value":"弘前大学大学院保健学研究科生体応答科学研究センター"},{"subitem_text_value":"Department of Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"},{"subitem_text_value":"R&D Center, Sekisui Chemical Co., Ltd."},{"subitem_text_value":"Research Center for Biomedical Sciences, Hirosaki University Graduate School of Health Sciences"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kudo, Fujimi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nishiguchi, Naoki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Ito, Kyoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakano, Manabu"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"Ito, Koichi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_63(2-4)_96.pdf","filesize":[{"value":"999.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_63(2-4)_96.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3747/files/HirosakiMedJ_63(2-4)_96.pdf"},"version_id":"569f3496-e8ca-4652-976d-49e078889618"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"P2Y受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"UDP-glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫抑制","subitem_subject_scheme":"Other"},{"subitem_subject":"P2Y receptor","subitem_subject_scheme":"Other"},{"subitem_subject":"UDP-glucose","subitem_subject_scheme":"Other"},{"subitem_subject":"macrophage","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammation","subitem_subject_scheme":"Other"},{"subitem_subject":"immune suppression","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Expression and Function of the P2y14 Receptor in Murine Peritoneal Macrophages","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Expression and Function of the P2y14 Receptor in Murine Peritoneal Macrophages"}]},"item_type_id":"3","owner":"3","path":["651"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-07"},"publish_date":"2012-12-07","publish_status":"0","recid":"3747","relation_version_is_last":true,"title":["Expression and Function of the P2y14 Receptor in Murine Peritoneal Macrophages"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:27:42.359709+00:00"}