{"created":"2023-05-15T09:02:51.808144+00:00","id":3750,"links":{},"metadata":{"_buckets":{"deposit":"c7ba1a79-db88-44cf-8e91-ca6e5599af66"},"_deposit":{"created_by":3,"id":"3750","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3750"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003750","sets":["557:561:651"]},"author_link":["13342","11731","11721","13348","13344","13340","12420","12425","12411","12416","13336","12423","13346","13337","12421","12410","11741","13345"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ヒト膵癌細胞におけるclaudin-1発現と浸潤性増殖の関連"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ヒト スイガン サイボウ ニオケル claudin 1 ハツゲン ト シンジュンセイ ゾウショク ノ カンレン"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2012-11-30","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2-4","bibliographicPageEnd":"135","bibliographicPageStart":"127","bibliographicVolumeNumber":"63","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Claudin is one of tight junction proteins which connect with the actin cytoskeleton and participate in the intracellular signaling. However, the significance of claudin in pancreatic cancer is understood not yet extensively. We examined the relationship between claudin-1 and invasion in PANC-1 and MIA PaCa-2 human pancreatic cancer cells, and investigated the functions of claudin-1 in invasive growth of pancreatic cancer cells. Claudin-1 knockdown by siRNA （claudin siRNA） affected the subcellular localization in the pancreatic cancer cells, and claudin-1 siRNA increased numbers of invasive pancreatic cancer PANC-1 and MIA PaCa-2 cells. Claudin-1 siRNA did not significantly affect expression levels of β-catenin, E-cadherin, α-smooth muscle actin, Bcl-2, and Bax in PANC-1 and MIA PaCa-2 cells. In addition, claudin-1 siRNA showed no significant change in the cell proliferation. We concluded that claudin-1 is significantly associated with invasive growth of human pancreatic cancer cells.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 63, 2012, p.127-135","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"12423","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コンドウ, ジュン"}]},{"nameIdentifiers":[{"nameIdentifier":"12421","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サトウ, フユキ"}]},{"nameIdentifiers":[{"nameIdentifier":"13340","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ゴ, ウンエン"}]},{"nameIdentifiers":[{"nameIdentifier":"11731","nameIdentifierScheme":"WEKO"}],"names":[{"name":"セイノ, ヒロコ"}]},{"nameIdentifiers":[{"nameIdentifier":"13342","nameIdentifierScheme":"WEKO"}],"names":[{"name":"モロハシ, サトコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12420","nameIdentifierScheme":"WEKO"}],"names":[{"name":"キジマ, ヒロシ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13344","nameIdentifierScheme":"WEKO"}],"names":[{"name":"近藤, 潤"}]},{"nameIdentifiers":[{"nameIdentifier":"13345","nameIdentifierScheme":"WEKO"}],"names":[{"name":"佐藤, 冬樹"}]},{"nameIdentifiers":[{"nameIdentifier":"13346","nameIdentifierScheme":"WEKO"}],"names":[{"name":"呉, 雲燕"}]},{"nameIdentifiers":[{"nameIdentifier":"11721","nameIdentifierScheme":"WEKO"}],"names":[{"name":"清野, 浩子"}]},{"nameIdentifiers":[{"nameIdentifier":"13348","nameIdentifierScheme":"WEKO"}],"names":[{"name":"諸橋, 聡子"}]},{"nameIdentifiers":[{"nameIdentifier":"12425","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"208","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/208_ja.html"}],"names":[{"name":"鬼島, 宏"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.65","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学研究科病理生命科学"},{"subitem_text_value":"Department of Pathology and Bioscience, Hirosaki"},{"subitem_text_value":"University Graduate School of Medicine, Hirosaki"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kondo, Jun"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Sato, Fuyuki"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Wu, Yunyan"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Seino, Hiroko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Morohashi, Satoko"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Kijima, Hiroshi"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_63(2-4)_127.pdf","filesize":[{"value":"1.2 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_63(2-4)_127.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3750/files/HirosakiMedJ_63(2-4)_127.pdf"},"version_id":"42675674-f4fd-47f8-8f41-6b6a0fcaa34a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"クローディン","subitem_subject_scheme":"Other"},{"subitem_subject":"タイトジャンクション","subitem_subject_scheme":"Other"},{"subitem_subject":"膵癌細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"浸潤性増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"claudin","subitem_subject_scheme":"Other"},{"subitem_subject":"tight junction","subitem_subject_scheme":"Other"},{"subitem_subject":"pancreatic cancer cells","subitem_subject_scheme":"Other"},{"subitem_subject":"invasive growth","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Claudin-1 Is Associated with Invasive Growth of Human Pancreatic Cancer Cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Claudin-1 Is Associated with Invasive Growth of Human Pancreatic Cancer Cells"}]},"item_type_id":"3","owner":"3","path":["651"],"pubdate":{"attribute_name":"公開日","attribute_value":"2012-12-07"},"publish_date":"2012-12-07","publish_status":"0","recid":"3750","relation_version_is_last":true,"title":["Claudin-1 Is Associated with Invasive Growth of Human Pancreatic Cancer Cells"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:05:43.300812+00:00"}