@article{oai:hirosaki.repo.nii.ac.jp:00003752,
 author = {Abe, Yukiko and Hu, Dong-Liang and Omoe, Katsuhiko and Fukuda, Ikuo and Nakane, Akio},
 issue = {2-4},
 journal = {弘前医学},
 month = {Nov},
 note = {Coagulase-negative staphylococci （CNS） are increasingly recognized to cause clinically significant infections. To investigate relationship of antibiotic resistance profiles, staphylococcal cassette chromosome mec （SCCmec） and superantigenic toxin genes in CNS, a total of 79 clinical CNS isolates from patients with surgical operations were comprehensively determined for minimum inhibitory concentration （MIC） of antibiotics, and searched for SCCmec and staphylococcal superantigenic toxin genes by novel multiplex PCR. Among 79 CNS isolates, at least one SCCmec gene was detected in 55 isolates （69.6%）. The most of SCCmec type was type III （36.7%）, and other detected types were type IVa（ 20.3%）, type II（ 19.0%）, type V（ 16.5%）, type I（ 15.2%）, and type IVb（ 3.8%）. The isolates with type I or IVa gene showed highly resistance to clindamycin and gentamicin, the isolates with type II showed more resistance to teicoplanin, the isolates with type III or type V showed more resistance to clindamycin. se and tst-1 genes were detected in none of the CNS isolates tested. These results suggested that there is high prevalence of SCCmec in clinical CNS isolates, and the SCCmec types are related to the resistances against specific antibiotics, but SCCmec do not related to superantigenic toxin genes in the CNS., 弘前医学. 63, 2012, p.143-153},
 pages = {143--153},
 title = {Comparative Prevalence of Antibiotic Resistance, Staphylococcal Cassette Chromosome Mec and Superantigenic Toxin Genes in Coagulase-Negative Staphylococci},
 volume = {63},
 year = {2012}
}