@article{oai:hirosaki.repo.nii.ac.jp:00003755,
 author = {Sakamoto, Yuichi and Narita, Koji and Nakane, Akio},
 issue = {1},
 journal = {弘前医学},
 month = {May},
 note = {Obesity leads to a state of chronic inflammation associated with increased levels of proinflammatory cytokines including interleukin-1β （IL-1β） that plays a critical role in host defense against Staphylococcus aureus infection. In this study, we investigated host defense against skin S. aureus infection in high-fat diet （HFD）-induced non-diabetic obesity by focusing on IL-1β production from subcutaneous adipose tissue derived-macrophages （SATDMs）. Bacterial numbers in skin lesions of HFD-fed mice were higher than those of normal-fat diet （ND）-fed control mice on day 3 after subcutaneous S. aureus infection. IL-1β production from SATDMs of HFD-fed mice was less than that of ND-fed mice after stimulation with formalin-killed S. aureus and ATP. In addition, NLRP3 mRNA expression and protein level of activated caspase-1 in SATDMs of HFD-fed mice were lower than those of NDfed mice after stimulation. Conversely, IL-1β production, NLRP3 mRNA expression and protein level of activated caspase-1 from visceral adipose tissue-derived macrophages of HFD-fed mice were higher than those of ND-fed mice. These results suggest that reduced IL-1β production in SATDMs of HFD-fed obese mice might be involved in impairment of host defense against skin S. aureus infection., 弘前医学. 64, 2013, p.29-40},
 pages = {29--40},
 title = {Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection},
 volume = {64},
 year = {2013}
}