{"created":"2023-05-15T09:02:52.123522+00:00","id":3755,"links":{},"metadata":{"_buckets":{"deposit":"723d5e41-0d3a-4cfc-8b40-dc23a1200064"},"_deposit":{"created_by":3,"id":"3755","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3755"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003755","sets":["557:561:652"]},"author_link":["12618","11486","11512","11492","11494","13453","13450","11501","13449"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"食餌性肥満マウスにおけるIL-1β産生減少にともなう皮膚黄色ブドウ球菌感染防御機能の低下"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ショクジセイ　ヒマン　マウス　ニオケル　IL-1β　サンセイ　ゲンショウ　ニ　トモナウ　ヒフ　オウショク　ブドウ　キュウキン　カンセン　ボウギョ　キノウ　ノ　テイカ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"40","bibliographicPageStart":"29","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Obesity leads to a state of chronic inflammation associated with increased levels of proinflammatory cytokines including interleukin-1β （IL-1β） that plays a critical role in host defense against Staphylococcus aureus infection. In this study, we investigated host defense against skin S. aureus infection in high-fat diet （HFD）-induced non-diabetic obesity by focusing on IL-1β production from subcutaneous adipose tissue derived-macrophages （SATDMs）. Bacterial numbers in skin lesions of HFD-fed mice were higher than those of normal-fat diet （ND）-fed control mice on day 3 after subcutaneous S. aureus infection. IL-1β production from SATDMs of HFD-fed mice was less than that of ND-fed mice after stimulation with formalin-killed S. aureus and ATP. In addition, NLRP3 mRNA expression and protein level of activated caspase-1 in SATDMs of HFD-fed mice were lower than those of NDfed mice after stimulation. Conversely, IL-1β production, NLRP3 mRNA expression and protein level of activated caspase-1 from visceral adipose tissue-derived macrophages of HFD-fed mice were higher than those of ND-fed mice. These results suggest that reduced IL-1β production in SATDMs of HFD-fed obese mice might be involved in impairment of host defense against skin S. aureus infection.","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64, 2013, p.29-40","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13450","nameIdentifierScheme":"WEKO"}],"names":[{"name":"サカモト, ユウイチ"}]},{"nameIdentifiers":[{"nameIdentifier":"11494","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナリタ, コウジ"}]},{"nameIdentifiers":[{"nameIdentifier":"11501","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ナカネ, アキオ"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13453","nameIdentifierScheme":"WEKO"}],"names":[{"name":"坂本, 勇一"}]},{"nameIdentifiers":[{"nameIdentifier":"11486","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"215","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/215_ja.html"}],"names":[{"name":"成田, 浩司"}]},{"nameIdentifiers":[{"nameIdentifier":"11492","nameIdentifierScheme":"WEKO"}],"names":[{"name":"中根, 明夫"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.7","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"内科系臨床医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"弘前大学大学院医学研究科感染生体防御学講座"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sakamoto, Yuichi"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Narita, Koji"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"Nakane, Akio"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64(1)_29.pdf","filesize":[{"value":"1.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64(1)_29.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3755/files/HirosakiMedJ_64(1)_29.pdf"},"version_id":"caaf050d-0fdb-4f47-bdcf-d69f31cc8b28"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Obesity","subitem_subject_scheme":"Other"},{"subitem_subject":"skin Staphylococcus aureus infection","subitem_subject_scheme":"Other"},{"subitem_subject":"interleukin-1β","subitem_subject_scheme":"Other"},{"subitem_subject":"inflammasome","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"黄色ブドウ球菌皮膚感染","subitem_subject_scheme":"Other"},{"subitem_subject":"インターロイキン‐1β","subitem_subject_scheme":"Other"},{"subitem_subject":"インフラマソーム","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection"}]},"item_type_id":"3","owner":"3","path":["652"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-02"},"publish_date":"2013-08-02","publish_status":"0","recid":"3755","relation_version_is_last":true,"title":["Reduced IL-1β Production in Diet-Induced Obese Mice Impairs Host Defense against Skin Staphylococcus Aureus Infection"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T11:21:35.588155+00:00"}