{"created":"2023-05-15T09:02:52.255437+00:00","id":3757,"links":{},"metadata":{"_buckets":{"deposit":"fb1b083a-911b-42bd-8b13-f1a7d46ca000"},"_deposit":{"created_by":3,"id":"3757","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3757"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003757","sets":["557:561:652"]},"author_link":["13470","12654","12641","12851","13458","13457","13459","12649","11328","12844","13469","12839","12639","12565","13462","11330","12657","13463","13456","12637","12570","12643","12640","13471","12562","11326","12636"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Identification of the Angiotensin Converting Enzyme Inhibitors in the Local Product of Aomori Prefecture"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"アオモリケン　トクサン　ショクザイ　ニ　ガンユウ　サレル　アンジオテンシン　ヘンカン　コウソ　ソガイ　ブッシツ　ノ　タンサク"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"57","bibliographicPageStart":"50","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本研究では，食事が多様な食品機能成分の摂取経路という一面を有し，疾病予防法を構築する上で有用な切り口であることを鑑み，アンジオテンシンＩから強力な血圧上昇を有するアンジオテンシンIIへの変換を司るアンジオテンシン変換酵素（ACE）を標的として，青森県特産の農産物及び水産物に含まれるACE阻害物質の探索を行った．青森県特産食材より蒸留水で抽出した抽出液について，ACE阻害活性の評価を行った．ACE阻害活性を示した抽出液から各種カラム分画法にてACE阻害活性物質を単離・精製し，質量分析法により，ACE阻害成分を同定した．その結果，カボチャ，ニンニク，大豆，大鰐モヤシの抽出液に特に強いACE阻害活性を見出した．その中から，カボチャを対象としてACE阻害活性成分の特定を試み，分子量303のムギネ酸前駆物質，ニコチアナミンがその機能実体である可能性を強く示唆する結果を得た．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64, 2013, p.50-57","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13463","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イタガキ, シロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"13462","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウチヤマ, ミチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12639","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カナザワ, サチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12641","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホソイ, カズヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テルイ, カズフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"12640","nameIdentifierScheme":"WEKO"}],"names":[{"name":"シモヤマ, リツコ"}]},{"nameIdentifiers":[{"nameIdentifier":"11328","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ツチダ, シゲキ"}]},{"nameIdentifiers":[{"nameIdentifier":"12654","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウエノ, シンヤ"}]},{"nameIdentifiers":[{"nameIdentifier":"12565","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ハヤカリ, マコト"}]}]},"item_3_full_name_3":{"attribute_name":"著者別名","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13470","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Itagaki, Shirou"}]},{"nameIdentifiers":[{"nameIdentifier":"13469","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Uchiyama, Michiko"}]},{"nameIdentifiers":[{"nameIdentifier":"13471","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Kanazawa, Sachiko"}]},{"nameIdentifiers":[{"nameIdentifier":"12637","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hosoi, Kazuhiro"}]},{"nameIdentifiers":[{"nameIdentifier":"12839","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Terui, Kazufumi"}]},{"nameIdentifiers":[{"nameIdentifier":"12636","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Shimoyama, Ritsuko"}]},{"nameIdentifiers":[{"nameIdentifier":"11330","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Tsuchida, Shigeki"}]},{"nameIdentifiers":[{"nameIdentifier":"12649","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"320","nameIdentifierScheme":"研究者総覧","nameIdentifierURI":"http://hue2.jm.hirosaki-u.ac.jp/html/320_ja.html"}],"names":[{"name":"Ueno, Shinya"}]},{"nameIdentifiers":[{"nameIdentifier":"12562","nameIdentifierScheme":"WEKO"}],"names":[{"name":"Hayakari, Makoto"}]}]},"item_3_publisher_35":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"弘前大学大学院医学研究科・弘前医学会"}]},"item_3_radio_42":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_radio_item":"Article"}]},"item_3_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AN00211444","subitem_source_identifier_type":"NCID"}]},"item_3_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0439-1721","subitem_source_identifier_type":"ISSN"}]},"item_3_subject_19":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"498.5","subitem_subject_scheme":"NDC"}]},"item_3_subject_23":{"attribute_name":"NIIサブジェクト","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"}]},"item_3_text_4":{"attribute_name":"著者所属","attribute_value_mlt":[{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"一般財団法人愛成会弘前愛成会病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部"},{"subitem_text_value":"弘前大学大学院医学研究科ゲノム生化学講座"},{"subitem_text_value":"弘前大学大学院医学研究科脳神経生理学講座"},{"subitem_text_value":"弘前大学医学部附属病院薬剤部 / 弘前大学大学院医学研究科薬剤学講座"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital"},{"subitem_text_value":"Department of Pharmacy, Hirosaki Aiseikai Hospital"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital"},{"subitem_text_value":"Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Neurophysiology, Hirosaki University Graduate School of Medicine"},{"subitem_text_value":"Department of Pharmacy, Hirosaki University School of Medicine & Hospital / Department of Pharmaceutical Sciences, Hirosaki University Graduate School of Medicine"}]},"item_3_version_type_18":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"板垣, 史郎"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"内山, 道子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"金澤, 佐知子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"細井, 一広"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"照井, 一史"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"下山, 律子"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"土田, 成紀"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"上野, 伸哉"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"早狩, 誠"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2018-03-13"}],"displaytype":"detail","filename":"HirosakiMedJ_64(1)_50.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"HirosakiMedJ_64(1)_50.pdf","url":"https://hirosaki.repo.nii.ac.jp/record/3757/files/HirosakiMedJ_64(1)_50.pdf"},"version_id":"fcddf137-e68b-4a38-a41b-0738c37949c7"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アンジオテンシン変換酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧症","subitem_subject_scheme":"Other"},{"subitem_subject":"カボチャ","subitem_subject_scheme":"Other"},{"subitem_subject":"特定保健用食品","subitem_subject_scheme":"Other"},{"subitem_subject":"ニコチアナミン","subitem_subject_scheme":"Other"},{"subitem_subject":"angiotensin-converting enzyme","subitem_subject_scheme":"Other"},{"subitem_subject":"hypertension","subitem_subject_scheme":"Other"},{"subitem_subject":"pumpkin","subitem_subject_scheme":"Other"},{"subitem_subject":"food for specified health use","subitem_subject_scheme":"Other"},{"subitem_subject":"nicotianamine","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"青森県特産食材に含有されるアンジオテンシン変換酵素阻害物質の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"青森県特産食材に含有されるアンジオテンシン変換酵素阻害物質の探索"}]},"item_type_id":"3","owner":"3","path":["652"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-08-02"},"publish_date":"2013-08-02","publish_status":"0","recid":"3757","relation_version_is_last":true,"title":["青森県特産食材に含有されるアンジオテンシン変換酵素阻害物質の探索"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-05-15T10:11:07.289523+00:00"}