{"created":"2023-05-15T09:02:52.320278+00:00","id":3758,"links":{},"metadata":{"_buckets":{"deposit":"85494dc1-2283-4083-8399-b98af11fb1ae"},"_deposit":{"created_by":3,"id":"3758","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"3758"},"status":"published"},"_oai":{"id":"oai:hirosaki.repo.nii.ac.jp:00003758","sets":["557:561:652"]},"author_link":["13518","13470","13514","13509","12641","13499","12851","13458","13457","13459","11474","12844","13469","13519","12839","12639","12565","13462","11478","13456","13463","12637","13524","12570","13505","13471","12562","13508","13500","11482"],"item_3_alternative_title_21":{"attribute_name":"その他のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study on Improvement of the Accuracy and Precision of Predicted Plasma Concentration of Vancomycin in the Administration Planning Support for Children"}]},"item_3_alternative_title_22":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"ショウニ　バンコマイシン　トウヨ　セッケイ　シエンジ　ニ　モチイ　ラレル　ケッチュウ　ノウド　ヨソクケイ　ノ　セイカクド　セイド　コウジョウ　ニ　カンスル　ケントウ"}]},"item_3_biblio_info_8":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-05-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"64","bibliographicPageStart":"58","bibliographicVolumeNumber":"64","bibliographic_titles":[{"bibliographic_title":"弘前医学"}]}]},"item_3_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"小児バンコマイシン（VCM）投与設計支援時に散見される，血中濃度予測値と実測値のずれの原因を特定し，予測系の正確度精度向上を図った．VCM投与時にTDMが実施された16歳以下の患者のうち，クレアチニンクリアランス（CLcr）値が推定可能であった25名を解析対象とした．初回VCM血中濃度ならびにVCMクリアランスを成人母集団パラメータ（A-PPK）および小児母集団パラメータ（P-PPK）を用いて予測し，実測値との差（残差）を基に予測系の正確度精度を評価した．また，初回VCM血中濃度について残差と患者背景因子との相関性を評価した．初回VCM血中濃度，VCMクリアランス共にA-PPK使用系の正確度精度が良好であった．A-PPK使用系の初回VCM血中濃度は年齢，体重，体表面積と有意に相関しており，年齢に関するカットオフ値は6歳と推定された．小児においてCLcrが推定できる場合は，6歳以上を目安にCLcrが組み込まれているA-PPKを用いることが推奨される．","subitem_description_type":"Abstract"}]},"item_3_description_7":{"attribute_name":"引用","attribute_value_mlt":[{"subitem_description":"弘前医学. 64, 2013, p.58-64","subitem_description_type":"Other"}]},"item_3_full_name_2":{"attribute_name":"著者(ヨミ)","attribute_value_mlt":[{"nameIdentifiers":[{"nameIdentifier":"13463","nameIdentifierScheme":"WEKO"}],"names":[{"name":"イタガキ, シロウ"}]},{"nameIdentifiers":[{"nameIdentifier":"13508","nameIdentifierScheme":"WEKO"}],"names":[{"name":"クドウ, マサキヨ"}]},{"nameIdentifiers":[{"nameIdentifier":"13509","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ニイオカ, タケノリ"}]},{"nameIdentifiers":[{"nameIdentifier":"13462","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ウチヤマ, ミチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12639","nameIdentifierScheme":"WEKO"}],"names":[{"name":"カナザワ, サチコ"}]},{"nameIdentifiers":[{"nameIdentifier":"12641","nameIdentifierScheme":"WEKO"}],"names":[{"name":"ホソイ, カズヒロ"}]},{"nameIdentifiers":[{"nameIdentifier":"12844","nameIdentifierScheme":"WEKO"}],"names":[{"name":"テルイ, カズフミ"}]},{"nameIdentifiers":[{"nameIdentifier":"13514","nameIdentifierScheme":"WEKO"}],"names":[{"name":"コジマ, 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